DegronMD

Uniprot ID: Q9NPI6

Source protein: mRNA-decapping enzyme 1A

Source gene: DCP1A

Class: DEG_SIAH_1

Location: 326:334

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9985

ASA_SCORE: 85.0778

COIL: 0.9577

CONS_SCORE: 0.397

DSS_SCORE: 0.6366

HELIX: 0.0191

FCONS_SCORE: 0.966

RIG_SCORE: 0.6502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R337Q	TCGA-AN-A046	BRCA	TCGA	APTAQVPPS	DEG_SIAH_1	0.25
p.R337Q	DO1285	BRCA	ICGC	APTAQVPPS	DEG_SIAH_1	0.25
p.R337Q	DO229005	COCA	ICGC	APTAQVPPS	DEG_SIAH_1	0.25
p.T328I	TCGA-B7-5816	STAD	TCGA	APTAQVPPS	DEG_SIAH_1	0.5966
p.V331A	TCGA-W3-AA1V	SKCM	TCGA	APTAQVPPS	DEG_SIAH_1	0.6936
p.P333T	TCGA-ZF-AA52	BLCA	TCGA	APTAQVPPS	DEG_SIAH_1	0.7031
p.Q334H	DO3043	BRCA	ICGC	APTAQVPPS	DEG_SIAH_1	0.7582
p.S326N	DO44440	HNSC	ICGC	APTAQVPPS	DEG_SIAH_1	0.7069
p.T321N	DO228948	LICA	ICGC	APTAQVPPS	DEG_SIAH_1	0.6389
p.T328N	DO229018	LICA	ICGC	APTAQVPPS	DEG_SIAH_1	0.5944
p.N319T	DO229453	SKCA	ICGC	APTAQVPPS	DEG_SIAH_1	0.5833
p.Q330H	SIDM01608	Endometrial Carcinoma	GDSC	APTAQVPPS	DEG_SIAH_1	0.647
p.Q330H	ACH-000990	Endometrial/Uterine Cancer	CCLE	APTAQVPPS	DEG_SIAH_1	0.647
p.Q334R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	APTAQVPPS	DEG_SIAH_1	0.7329
p.H327Y	HCC1419	breast	COSMIC	APTAQVPPS	DEG_SIAH_1	0.7229
p.S329T	WM-115	skin	COSMIC	APTAQVPPS	DEG_SIAH_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPI6	mRNA-decapping enzyme 1A	DEG_SIAH_1	326:334	APTAQVPPS	SIAH1,SIAH2,SIAH3	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons