DegronMD - Q9NPI6(DCP1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R337Q	TCGA-AN-A046	BRCA	TCGA	APTAQVPPS	DEG_SIAH_1	326:334	Mutation rewiring degron network	0.25
p.R337Q	DO1285	BRCA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation rewiring degron network	0.25
p.R337Q	DO229005	COCA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation rewiring degron network	0.25
p.T328I	TCGA-B7-5816	STAD	TCGA	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.5966
p.Q270E	TCGA-DR-A0ZM	CESC	TCGA	SETLGVPSA	DEG_COP1_1	271:279	Mutation rewiring degron network	0.3056
p.Q270E	DO6254	CESC	ICGC	SETLGVPSA	DEG_COP1_1	271:279	Mutation rewiring degron network	0.3056
p.P269L	TCGA-EB-A5FP	SKCM	TCGA	SETLGVPSA	DEG_COP1_1	271:279	Mutation rewiring degron network	0.2778
p.L274M	TCGA-VQ-A8P2	STAD	TCGA	SETLGVPSA	DEG_COP1_1	271:279	Mutation altering degron motif	0.5999
p.V331A	TCGA-W3-AA1V	SKCM	TCGA	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.6936
p.P333T	TCGA-ZF-AA52	BLCA	TCGA	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7031
p.Q334H	DO3043	BRCA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7582
p.S326N	DO44440	HNSC	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7069
p.T321N	DO228948	LICA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation blocking phosphorylation signal	0.6389
p.T328N	DO229018	LICA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.5944
p.N319T	DO229453	SKCA	ICGC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation blocking phosphorylation signal	0.5833
p.P275Q	DO47552	SKCM	ICGC	SETLGVPSA	DEG_COP1_1	271:279	Mutation altering degron motif	0.7035
p.Q330H	SIDM01608	Endometrial Carcinoma	GDSC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.647
p.Q330H	ACH-000990	Endometrial/Uterine Cancer	CCLE	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.647
p.Q334R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7329
p.H327Y	HCC1419	breast	COSMIC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7229
p.S329T	WM-115	skin	COSMIC	APTAQVPPS	DEG_SIAH_1	326:334	Mutation altering degron motif	0.7116

Kaplan plot for DCP1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCP1A

UniProt ID: Q9NPI6

Entrez ID: 55802

Protein name: mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCP1A in