DegronMD

Uniprot ID: Q9NPI6

Source protein: mRNA-decapping enzyme 1A

Source gene: DCP1A

Class: DEG_COP1_1

Location: 271:279

E3 ligase: COP1

DEGRON score: 0.997

ASA_SCORE: 75

COIL: 0.798

CONS_SCORE: 0.4106

DSS_SCORE: 0.6188

HELIX: 0.1577

FCONS_SCORE: 1.0196

RIG_SCORE: 0.6341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q270E	TCGA-DR-A0ZM	CESC	TCGA	SETLGVPSA	DEG_COP1_1	0.3056
p.Q270E	DO6254	CESC	ICGC	SETLGVPSA	DEG_COP1_1	0.3056
p.P269L	TCGA-EB-A5FP	SKCM	TCGA	SETLGVPSA	DEG_COP1_1	0.2778
p.L274M	TCGA-VQ-A8P2	STAD	TCGA	SETLGVPSA	DEG_COP1_1	0.5999
p.P275Q	DO47552	SKCM	ICGC	SETLGVPSA	DEG_COP1_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPI6	mRNA-decapping enzyme 1A	DEG_COP1_1	271:279	SETLGVPSA	COP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons