DegronMD

Uniprot ID: Q16633

Source protein: POU domain class 2-associating factor 1

Source gene: POU2AF1

Class: DEG_SIAH_1

Location: 46:54

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9911

ASA_SCORE: 62.7

COIL: 0.7126

CONS_SCORE: 0.851

DSS_SCORE: 0.4339

HELIX: 0.0339

FCONS_SCORE: 1.0965

RIG_SCORE: 0.7248

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A49V	TCGA-OR-A5J5	ACC	TCGA	APTAVVLPH	DEG_SIAH_1	0.6936
p.A58V	DO8264	COAD	ICGC	APTAVVLPH	DEG_SIAH_1	0.2222
p.A58V	DO231941	LICA	ICGC	APTAVVLPH	DEG_SIAH_1	0.2222
p.A58E	DO229018	LICA	ICGC	APTAVVLPH	DEG_SIAH_1	0.2222
p.A39T	TCGA-B5-A3FC	UCEC	TCGA	APTAVVLPH	DEG_SIAH_1	0.1389
p.A39T	DO41871	UCEC	ICGC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM00210	Ovarian Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM00971	Breast Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM00254	Neuroblastoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.T61A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.1389
p.R36Q	SIDM00373	Endometrial Carcinoma	GDSC	APTAVVLPH	DEG_SIAH_1	0.0556
p.R36Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	APTAVVLPH	DEG_SIAH_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16633	POU domain class 2-associating factor 1	DEG_SIAH_1	46:54	APTAVVLPH	SIAH1,SIAH2,SIAH3	0.9911	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons