DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4766:4770

E3 ligase: SPOP

DEGRON score: 0.6455

ASA_SCORE: 91.26

COIL: 0.8898

CONS_SCORE: 0.295

DSS_SCORE: 0.4762

HELIX: 0.0208

FCONS_SCORE: 1.0797

RIG_SCORE: 0.7643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4766T	TCGA-06-5416	GBM	TCGA	AQTTT	DEG_SPOP_SBC_1	0.7139
p.T4761M	TCGA-22-4591	LUSC	TCGA	AQTTT	DEG_SPOP_SBC_1	0.1944
p.T4761M	TCGA-G3-A5SI	LIHC	TCGA	AQTTT	DEG_SPOP_SBC_1	0.1944
p.T4761M	TCGA-IB-7651	PAAD	TCGA	AQTTT	DEG_SPOP_SBC_1	0.1944
p.T4768A	TCGA-AP-A056	UCEC	TCGA	AQTTT	DEG_SPOP_SBC_1	0.7139
p.T4768P	TCGA-DK-A6AW	BLCA	TCGA	AQTTT	DEG_SPOP_SBC_1	0.7031
p.H4779N	TCGA-EE-A2MN	SKCM	TCGA	AQTTT	DEG_SPOP_SBC_1	0.0833
p.T4771P	DO48566	BLCA	ICGC	AQTTT	DEG_SPOP_SBC_1	0.3056
p.S4758C	DO5500	BRCA	ICGC	AQTTT	DEG_SPOP_SBC_1	0.1111
p.S4758C	DO44456	HNSC	ICGC	AQTTT	DEG_SPOP_SBC_1	0.1111
p.S4758C	DO220239	SARC	ICGC	AQTTT	DEG_SPOP_SBC_1	0.1111
p.A4769T	DO10880	GBM	ICGC	AQTTT	DEG_SPOP_SBC_1	0.7139
p.T4764M	DO48475	LIHC	ICGC	AQTTT	DEG_SPOP_SBC_1	0.2778
p.T4764M	DO26620	LUSC	ICGC	AQTTT	DEG_SPOP_SBC_1	0.2778
p.T4764M	DO46657	PAAD	ICGC	AQTTT	DEG_SPOP_SBC_1	0.2778
p.P4757L	DO25837	LUAD	ICGC	AQTTT	DEG_SPOP_SBC_1	0.0833
p.M4778L	DO218856	SKCA	ICGC	AQTTT	DEG_SPOP_SBC_1	0.1111
p.T4771A	DO43971	UCEC	ICGC	AQTTT	DEG_SPOP_SBC_1	0.3056
p.P4771L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AQTTT	DEG_SPOP_SBC_1	0.3056
p.P4771L	ACH-000647	Esophageal Cancer	CCLE	AQTTT	DEG_SPOP_SBC_1	0.3056
p.P4771L	TE-1	oesophagus	COSMIC	AQTTT	DEG_SPOP_SBC_1	0.3056
p.P4771S	ACH-001301	Neuroblastoma	CCLE	AQTTT	DEG_SPOP_SBC_1	0.3056
p.S4756P	ACH-002122	Lung Cancer	CCLE	AQTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4766:4770	AQTTT	SPOP	0.6455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons