DegronMD

Uniprot ID: P41250

Source protein: Glycine--tRNA ligase

Source gene: GARS1

Class: DEG_APCC_DBOX_1

Location: 12:20

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6696

ASA_SCORE: 47.6667

COIL: 0.2848

CONS_SCORE: 0.288

DSS_SCORE: 0.0504

HELIX: 0.6581

FCONS_SCORE: 1.3646

RIG_SCORE: 0.8608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L20P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ARAALLLLL	DEG_APCC_DBOX_1	0.6471
p.L20P	SIDM00660	Colorectal Carcinoma	GDSC	ARAALLLLL	DEG_APCC_DBOX_1	0.6471
p.P6T	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ARAALLLLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41250	Glycine--tRNA ligase	DEG_APCC_DBOX_1	12:20	ARAALLLLL	APC,CDC20,FZR1	0.6696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons