DegronMD

Uniprot ID: O14737

Source protein: Programmed cell death protein 5

Source gene: PDCD5

Class: DEG_APCC_DBOX_1

Location: 52:60

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6061

ASA_SCORE: 46.4778

COIL: 0.1557

CONS_SCORE: 0.8637

DSS_SCORE: 0.2784

HELIX: 0.8407

FCONS_SCORE: 1.054

RIG_SCORE: 0.7654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53Q	TCGA-55-A4DF	LUAD	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	0.7329
p.R53Q	DO45318	LUAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.7329
p.S57G	TCGA-AD-6895	COAD	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	0.6993
p.S57G	DO8938	COAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.6993
p.P64T	TCGA-CZ-4864	KIRC	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	0.2222
p.P64T	DO16178	KIRC	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.2222
p.A69V	DO50320	ESAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.0833
p.Q64H	DO234230	ESAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.2222
p.V62L	DO228952	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.2778
p.R53L	DO228985	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.8428
p.C56F	DO229025	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.7108
p.R55M	DO229036	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.7521
p.R63K	DO229050	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.6944
p.R58T	DO46808	PRAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	0.7876
p.L61R	SIDM00935	Other Solid Cancers	GDSC	ARARLSNLA	DEG_APCC_DBOX_1	0.3056
p.L61R	ACH-002091	Skin Cancer	CCLE	ARARLSNLA	DEG_APCC_DBOX_1	0.3056
p.L61R	CAL-39	vulva	COSMIC	ARARLSNLA	DEG_APCC_DBOX_1	0.3056
p.R55S	SIDM00643	Non-Cancerous	GDSC	ARARLSNLA	DEG_APCC_DBOX_1	0.6316
p.I57V	NCI-H1770	lung	COSMIC	ARARLSNLA	DEG_APCC_DBOX_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14737	Programmed cell death protein 5	DEG_APCC_DBOX_1	52:60	ARARLSNLA	APC,CDC20,FZR1	0.6061	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons