DegronMD - O14737(PDCD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R53Q	TCGA-55-A4DF	LUAD	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7329
p.R53Q	DO45318	LUAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7329
p.S57G	TCGA-AD-6895	COAD	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.6993
p.S57G	DO8938	COAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.6993
p.P24S	TCGA-AP-A1DV	UCEC	TCGA	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1667
p.P24S	DO43186	UCEC	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1667
p.A27S	TCGA-CN-6010	HNSC	TCGA	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.0833
p.A27S	DO14766	HNSC	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.0833
p.P64T	TCGA-CZ-4864	KIRC	TCGA	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.2222
p.P64T	DO16178	KIRC	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.2222
p.A69V	DO50320	ESAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.0833
p.Q64H	DO234230	ESAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.2222
p.V62L	DO228952	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.2778
p.R53L	DO228985	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.8428
p.C56F	DO229025	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7108
p.R55M	DO229036	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7521
p.R63K	DO229050	LICA	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation blocking ubiquitination signal	0.6944
p.A28V	DO51180	PAEN	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.0556
p.R58T	DO46808	PRAD	ICGC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7876
p.A15D	DO229272	THCA	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.6682
p.L61R	SIDM00935	Other Solid Cancers	GDSC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.3056
p.L61R	ACH-002091	Skin Cancer	CCLE	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.3056
p.L61R	CAL-39	vulva	COSMIC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.3056
p.R55S	SIDM00643	Non-Cancerous	GDSC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.6316
p.A8S	SIDM01728	Endometrial Carcinoma	GDSC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.2778
p.A8S	ACH-000173	Endometrial/Uterine Cancer	CCLE	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.2778
p.A8S	ACH-000495	Kidney Cancer	CCLE	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.2778
p.E16K	SIDM01752	Pancreatic Carcinoma	GDSC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.591
p.L23R	CAL-39	vulva	COSMIC	RRQRLAELQ	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1944
p.I57V	NCI-H1770	lung	COSMIC	ARARLSNLA	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.7076

Kaplan plot for PDCD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDCD5

UniProt ID: O14737

Entrez ID: 9141

Protein name: Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDCD5 in