DegronMD

Uniprot ID: O14737

Source protein: Programmed cell death protein 5

Source gene: PDCD5

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5029

ASA_SCORE: 110.4889

COIL: 0.1602

CONS_SCORE: 0.7182

DSS_SCORE: 0.5862

HELIX: 0.8439

FCONS_SCORE: 1.0473

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P24S	TCGA-AP-A1DV	UCEC	TCGA	RRQRLAELQ	DEG_APCC_DBOX_1	0.1667
p.P24S	DO43186	UCEC	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	0.1667
p.A27S	TCGA-CN-6010	HNSC	TCGA	RRQRLAELQ	DEG_APCC_DBOX_1	0.0833
p.A27S	DO14766	HNSC	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	0.0833
p.A28V	DO51180	PAEN	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	0.0556
p.A15D	DO229272	THCA	ICGC	RRQRLAELQ	DEG_APCC_DBOX_1	0.6682
p.A8S	SIDM01728	Endometrial Carcinoma	GDSC	RRQRLAELQ	DEG_APCC_DBOX_1	0.2778
p.A8S	ACH-000173	Endometrial/Uterine Cancer	CCLE	RRQRLAELQ	DEG_APCC_DBOX_1	0.2778
p.A8S	ACH-000495	Kidney Cancer	CCLE	RRQRLAELQ	DEG_APCC_DBOX_1	0.2778
p.E16K	SIDM01752	Pancreatic Carcinoma	GDSC	RRQRLAELQ	DEG_APCC_DBOX_1	0.591
p.L23R	CAL-39	vulva	COSMIC	RRQRLAELQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14737	Programmed cell death protein 5	DEG_APCC_DBOX_1	10:18	RRQRLAELQ	APC,CDC20,FZR1	0.5029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons