DegronMD

Uniprot ID: P46779

Source protein: 60S ribosomal protein L28

Source gene: RPL28

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9735

ASA_SCORE: 66.5111

COIL: 0.2911

CONS_SCORE: 0.6947

DSS_SCORE: 0.4536

HELIX: 0.6637

FCONS_SCORE: 1.0078

RIG_SCORE: 0.7825

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R79L	TCGA-22-5489	LUSC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.1389
p.T89M	TCGA-2J-AAB1	PAAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.7423
p.T89M	DO51652	PAAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.7423
p.V78M	TCGA-4R-AA8I	LIHC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.1111
p.V78M	DO49657	LIHC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1111
p.I82V	TCGA-85-8276	LUSC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.2222
p.I82V	DO26436	LUSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.2222
p.V78A	TCGA-A5-A0G2	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.1111
p.V78A	DO41235	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1111
p.R87H	TCGA-AP-A059	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.8244
p.R87H	DO41361	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.8244
p.R98H	TCGA-AX-A2HG	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.2222
p.R98H	DO41337	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.2222
p.T80N	TCGA-AY-A8YK	COAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.6111
p.T80N	DO51727	COAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.6111
p.S91R	TCGA-B8-5551	KIRC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.7427
p.S91R	DO19068	KIRC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.7427
p.R103H	TCGA-BR-7707	STAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.0833
p.R103H	DO38487	STAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.0833
p.R87C	TCGA-KB-A93G	STAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	0.8301
p.R87C	DO222335	STAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.8301
p.P81S	DO225261	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1944
p.P81S	DO220887	MELA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1944
p.P81S	SK-OV-3	ovary	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.1944
p.R79Q	DO224768	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1389
p.H80Y	DO50058	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.6111
p.R83L	DO3674	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.25
p.S100C	DO222848	BTCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.1667
p.R77T	DO51595	CESC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.5278
p.A88V	DO222492	COCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.5825
p.P82L	DO14678	HNSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.2222
p.A76S	DO229028	LICA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.0556
p.A76T	DO26414	LUAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.0556
p.W85L	DO26710	LUSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.3056
p.R77I	DO38011	SKCM	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.5278
p.S92I	DO229275	THCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.7341
p.R83C	DO41331	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	0.25
p.S76Y	SIDM00282	Colorectal Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	0.0556
p.S76Y	ACH-000998	Colon/Colorectal Cancer	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	0.0556
p.S76Y	CW-2	large_intestine	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.0556
p.R94K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	0.6126
p.R94K	ACH-000980	Lung Cancer	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	0.6126
p.R94K	NCI-H1155	lung	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.6126
p.P80S	SIDM01617	Endometrial Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	0.6111
p.N85D	ACH-000167	Myeloma	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	0.3056
p.A81V	NCI-SNU-16	stomach	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.1944
p.D88N	NCI-H1155	lung	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.6932
p.R78K	MDST8	large_intestine	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARATLSSIR

Degron related mutations and impact score

Drug responses associated with RPL28 mutations

All proteins holding degron of ARATLSSIR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46779	60S ribosomal protein L28	DEG_APCC_DBOX_1	86:94	ARATLSSIR	APC,CDC20,FZR1	0.9735	More...