DegronMD - P46779(RPL28)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R79L	TCGA-22-5489	LUSC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389
p.T89M	TCGA-2J-AAB1	PAAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.7423
p.T89M	DO51652	PAAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.7423
p.V78M	TCGA-4R-AA8I	LIHC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111
p.V78M	DO49657	LIHC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111
p.I18M	TCGA-69-7980	LUAD	TCGA	NKQTYSTEP	CBL_PTK	21:29	Mutation rewiring degron network	0.25
p.I18M	DO218030	GACA	ICGC	NKQTYSTEP	CBL_PTK	21:29	Mutation rewiring degron network	0.25
p.I18M	DO23678	LUAD	ICGC	NKQTYSTEP	CBL_PTK	21:29	Mutation rewiring degron network	0.25
p.I82V	TCGA-85-8276	LUSC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.2222
p.I82V	DO26436	LUSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.2222
p.V78A	TCGA-A5-A0G2	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111
p.V78A	DO41235	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111
p.R87H	TCGA-AP-A059	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.8244
p.R87H	DO41361	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.8244
p.R98H	TCGA-AX-A2HG	UCEC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.2222
p.R98H	DO41337	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.2222
p.T80N	TCGA-AY-A8YK	COAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.6111
p.T80N	DO51727	COAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.6111
p.S91R	TCGA-B8-5551	KIRC	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.7427
p.S91R	DO19068	KIRC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.7427
p.R103H	TCGA-BR-7707	STAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.R103H	DO38487	STAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.S14P	TCGA-CM-5860	COAD	TCGA	NKQTYSTEP	CBL_PTK	21:29	Mutation blocking phosphorylation signal	0.5833
p.S14P	DO10542	COAD	ICGC	NKQTYSTEP	CBL_PTK	21:29	Mutation blocking phosphorylation signal	0.5833
p.K22E	TCGA-D1-A15X	UCEC	TCGA	NKQTYSTEP	CBL_PTK	21:29	Mutation altering degron motif	0.591
p.K22E	DO43274	UCEC	ICGC	NKQTYSTEP	CBL_PTK	21:29	Mutation altering degron motif	0.591
p.R87C	TCGA-KB-A93G	STAD	TCGA	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.8301
p.R87C	DO222335	STAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.8301
p.S37F	TCGA-WE-A8ZQ	SKCM	TCGA	NKQTYSTEP	CBL_PTK	21:29	Mutation blocking phosphorylation signal	0.5556
p.S37F	DO51288	SKCM	ICGC	NKQTYSTEP	CBL_PTK	21:29	Mutation blocking phosphorylation signal	0.5556
p.P81S	DO225261	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1944
p.P81S	DO220887	MELA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1944
p.P81S	SK-OV-3	ovary	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1944
p.R79Q	DO224768	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389
p.H80Y	DO50058	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.6111
p.R83L	DO3674	BRCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.25
p.S100C	DO222848	BTCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1667
p.R77T	DO51595	CESC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.5278
p.A88V	DO222492	COCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5825
p.P82L	DO14678	HNSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.2222
p.A76S	DO229028	LICA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.A76T	DO26414	LUAD	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.W85L	DO26710	LUSC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.3056
p.R77I	DO38011	SKCM	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.5278
p.S92I	DO229275	THCA	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.7341
p.R83C	DO41331	UCEC	ICGC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.25
p.S76Y	SIDM00282	Colorectal Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.S76Y	ACH-000998	Colon/Colorectal Cancer	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.S76Y	CW-2	large intestine	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.R94K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6126
p.R94K	ACH-000980	Lung Cancer	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6126
p.R94K	NCI-H1155	lung	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6126
p.P80S	SIDM01617	Endometrial Carcinoma	GDSC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation blocking phosphorylation signal	0.6111
p.N85D	ACH-000167	Myeloma	CCLE	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.3056
p.A81V	NCI-SNU-16	stomach	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1944
p.D88N	NCI-H1155	lung	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6932
p.R78K	MDST8	large intestine	COSMIC	ARATLSSIR	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPL28

UniProt ID: P46779

Entrez ID: 6158

Protein name: 60S ribosomal protein L28 (Large ribosomal subunit protein eL28)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPL28 in