DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NKQTYSTEP
Uniprot ID:
P46779
Source protein:
60S ribosomal protein L28
Source gene:
RPL28
Class:
CBL_PTK
Location:
21:29
E3 ligase:
CBL
DEGRON score:
0.8521
ASA_SCORE:
88.8
COIL:
0.5978
CONS_SCORE:
0.7488
DSS_SCORE:
0.4137
HELIX:
0.033
FCONS_SCORE:
0.9883
RIG_SCORE:
0.7675
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I18M
TCGA-69-7980
LUAD
TCGA
NKQTYSTEP
CBL_PTK
0.25
p.I18M
DO218030
GACA
ICGC
NKQTYSTEP
CBL_PTK
0.25
p.I18M
DO23678
LUAD
ICGC
NKQTYSTEP
CBL_PTK
0.25
p.S14P
TCGA-CM-5860
COAD
TCGA
NKQTYSTEP
CBL_PTK
0.5833
p.S14P
DO10542
COAD
ICGC
NKQTYSTEP
CBL_PTK
0.5833
p.K22E
TCGA-D1-A15X
UCEC
TCGA
NKQTYSTEP
CBL_PTK
0.591
p.K22E
DO43274
UCEC
ICGC
NKQTYSTEP
CBL_PTK
0.591
p.S37F
TCGA-WE-A8ZQ
SKCM
TCGA
NKQTYSTEP
CBL_PTK
0.5556
p.S37F
DO51288
SKCM
ICGC
NKQTYSTEP
CBL_PTK
0.5556
Drug responses associated with RPL28 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKQTYSTEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46779
60S ribosomal protein L28
CBL_PTK
21:29
NKQTYSTEP
CBL
0.8521
More...
