DegronMD

Uniprot ID: O75106

Source protein: Retina-specific copper amine oxidase

Source gene: AOC2

Class: DEG_APCC_DBOX_1

Location: 117:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7181

ASA_SCORE: 17.3667

COIL: 0.1258

CONS_SCORE: 0.59

DSS_SCORE: 0.4393

HELIX: 0.017

FCONS_SCORE: 1.2864

RIG_SCORE: 0.7791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I123V	TCGA-33-4566	LUSC	TCGA	AREALAIVL	DEG_APCC_DBOX_1	0.5965
p.I123V	DO26790	LUSC	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.5965
p.I123T	TCGA-A3-3370	KIRC	TCGA	AREALAIVL	DEG_APCC_DBOX_1	0.5966
p.I123T	DO18452	KIRC	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.5966
p.P114L	TCGA-CN-5373	HNSC	TCGA	AREALAIVL	DEG_APCC_DBOX_1	0.25
p.P114L	DO16101	HNSC	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.25
p.V124I	TCGA-IB-7651	PAAD	TCGA	AREALAIVL	DEG_APCC_DBOX_1	0.5965
p.V124I	DO46657	PAAD	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.5965
p.R118W	TCGA-L5-A4OI	ESCA	TCGA	AREALAIVL	DEG_APCC_DBOX_1	0.8634
p.E119D	DO229015	LICA	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.5647
p.A122S	DO229026	LICA	ICGC	AREALAIVL	DEG_APCC_DBOX_1	0.6477
p.R118Q	SIDM00045	Gastric Carcinoma	GDSC	AREALAIVL	DEG_APCC_DBOX_1	0.7329
p.R118Q	ACH-002141	Gastric Cancer	CCLE	AREALAIVL	DEG_APCC_DBOX_1	0.7329
p.R118Q	HSC-39	stomach	COSMIC	AREALAIVL	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75106	Retina-specific copper amine oxidase	DEG_APCC_DBOX_1	117:125	AREALAIVL	APC,CDC20,FZR1	0.7181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons