DegronMD

Uniprot ID: Q5VWG9

Source protein: Transcription initiation factor TFIID subunit 3

Source gene: TAF3

Class: DEG_APCC_DBOX_1

Location: 212:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9749

ASA_SCORE: 89.4778

COIL: 0.8102

CONS_SCORE: 0.4698

DSS_SCORE: 0.3972

HELIX: 0.1282

FCONS_SCORE: 1.1015

RIG_SCORE: 0.7439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V207F	TCGA-A3-3383	KIRC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.1944
p.S229Y	TCGA-AX-A2HC	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.5278
p.S229Y	DO41572	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.5278
p.D203N	TCGA-BR-A4QL	STAD	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.0833
p.D203N	DO38723	STAD	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.0833
p.R213Q	TCGA-BS-A0UV	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.7329
p.R213Q	DO42793	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.7329
p.D206N	TCGA-CR-7370	HNSC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.1667
p.D206N	DO14426	HNSC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.1667
p.A212V	TCGA-DA-A95Z	SKCM	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.5825
p.A212V	DO219481	SKCM	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.5825
p.L228R	TCGA-NK-A5CR	LUSC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	0.1111
p.L228R	DO219207	LUSC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.1111
p.Q222P	DO228750	GACA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.2778
p.L205I	DO44810	LICA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.1389
p.D203Y	DO51479	PACA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	0.0833
p.T221A	SIDM01608	Endometrial Carcinoma	GDSC	AREPLSSIN	DEG_APCC_DBOX_1	0.3056
p.T221A	ACH-000990	Endometrial/Uterine Cancer	CCLE	AREPLSSIN	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWG9	Transcription initiation factor TFIID subunit 3	DEG_APCC_DBOX_1	212:220	AREPLSSIN	APC,CDC20,FZR1	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons