DegronMD

Uniprot ID: Q14517

Source protein: Protocadherin Fat 1

Source gene: FAT1

Class: DEG_APCC_DBOX_1

Location: 4358:4366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9659

ASA_SCORE: 86.1333

COIL: 0.6378

CONS_SCORE: 0.3704

DSS_SCORE: 0.5452

HELIX: 0.1056

FCONS_SCORE: 0.9869

RIG_SCORE: 0.6897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4375L	TCGA-AP-A1DV	UCEC	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833
p.S4375L	TCGA-EE-A29R	SKCM	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833
p.S4375L	DO232761	PBCA	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833
p.S4375L	DO37448	SKCM	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833
p.S4375L	DO43186	UCEC	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833
p.F4371L	TCGA-CX-7085	HNSC	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.1944
p.F4371L	DO14758	HNSC	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.1944
p.S4367C	TCGA-CX-7085	HNSC	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.3056
p.S4367C	DO14758	HNSC	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.3056
p.E4374K	TCGA-EI-6917	READ	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.1111
p.E4374K	DO36881	READ	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.1111
p.S4373F	TCGA-JX-A3Q0	CESC	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.1389
p.S4373F	DO51607	CESC	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.1389
p.S4367F	TCGA-W3-AA1W	SKCM	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.3056
p.S4367F	DO51277	SKCM	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.3056
p.E4364K	TCGA-ZF-A9RC	BLCA	TCGA	ARESLSEVQ	DEG_APCC_DBOX_1	0.591
p.E4364K	DO219068	BLCA	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.591
p.Y4356H	DO27851	MALY	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.7222
p.Q4366H	DO229253	THCA	ICGC	ARESLSEVQ	DEG_APCC_DBOX_1	0.647
p.P4349S	HT-1080	soft_tissue	COSMIC	ARESLSEVQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14517	Protocadherin Fat 1	DEG_APCC_DBOX_1	4358:4366	ARESLSEVQ	APC,CDC20,FZR1	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons