DegronMD

Uniprot ID: Q8IY21

Source protein: Probable ATP-dependent RNA helicase DDX60

Source gene: DDX60

Class: DEG_APCC_DBOX_1

Location: 736:744

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8303

ASA_SCORE: 40.4444

COIL: 0.2047

CONS_SCORE: 0.5291

DSS_SCORE: 0.2579

HELIX: 0.7526

FCONS_SCORE: 1.327

RIG_SCORE: 0.8065

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y742S	TCGA-06-5416	GBM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.6009
p.Y742S	DO10880	GBM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.6009
p.R737W	TCGA-14-1823	GBM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	TCGA-VP-A87H	PRAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	DO12070	GBM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	DO51389	PRAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	SIDM01104	Melanoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	ACH-000640	Skin Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.R737W	SK-MEL-31	skin	COSMIC	ARFQLQYMG	DEG_APCC_DBOX_1	0.8634
p.K728T	TCGA-AA-3977	COAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.2222
p.K728T	TCGA-B5-A1MR	UCEC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.2222
p.K728T	DO8730	COAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.2222
p.K728T	DO41758	UCEC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.2222
p.R737Q	TCGA-CM-6677	COAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.R737Q	TCGA-K1-A6RV	SARC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.R737Q	DO8570	COAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.R737Q	DO220197	SARC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.R737Q	SIDM01394	Kidney Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.R737Q	ACH-000907	Kidney Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	0.7329
p.P735Q	TCGA-D3-A2JO	SKCM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.3056
p.P735Q	DO47619	SKCM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.3056
p.P735T	TCGA-DX-A1KX	SARC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.3056
p.P735T	DO219946	SARC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.3056
p.R752K	TCGA-FS-A1ZK	SKCM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	0.1111
p.R752K	DO37474	SKCM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1111
p.G744S	DO45169	LIRI	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.5882
p.R749Q	DO227832	PBCA	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00627	Cervical Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00025	Head and Neck Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM01002	Breast Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00474	Ovarian Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM01148	Plasma Cell Myeloma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00853	Other Sarcomas	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00752	Non-Cancerous	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.V731I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.1944
p.L740P	SIDM01612	Endometrial Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	0.7582
p.L740P	ACH-000946	Endometrial/Uterine Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	0.7582
p.A736T	ACH-000958	Colon/Colorectal Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARFQLQYMG

Degron related mutations and impact score

Drug responses associated with DDX60 mutations

All proteins holding degron of ARFQLQYMG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY21	Probable ATP-dependent RNA helicase DDX60	DEG_APCC_DBOX_1	736:744	ARFQLQYMG	APC,CDC20,FZR1	0.8303	More...