DegronMD - Q8IY21(DDX60)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y742S	TCGA-06-5416	GBM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6009
p.Y742S	DO10880	GBM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6009
p.R737W	TCGA-14-1823	GBM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	TCGA-VP-A87H	PRAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	DO12070	GBM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	DO51389	PRAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	SIDM01104	Melanoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	ACH-000640	Skin Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.R737W	SK-MEL-31	skin	COSMIC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8634
p.L1105F	TCGA-34-8454	LUSC	TCGA	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.1944
p.L1105F	DO50094	LUSC	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.1944
p.E1108K	TCGA-3N-A9WD	SKCM	TCGA	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.1111
p.E1108K	DO51235	SKCM	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.1111
p.V977L	TCGA-55-6979	LUAD	TCGA	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation altering degron motif	0.5654
p.V977L	TCGA-55-6979	LUAD	TCGA	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation altering degron motif	0.5654
p.V977L	DO24110	LUAD	ICGC	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation altering degron motif	0.5654
p.V977L	DO24110	LUAD	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation altering degron motif	0.5654
p.K728T	TCGA-AA-3977	COAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation substituting flanking lysine	0.2222
p.K728T	TCGA-B5-A1MR	UCEC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation substituting flanking lysine	0.2222
p.K728T	DO8730	COAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation substituting flanking lysine	0.2222
p.K728T	DO41758	UCEC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation substituting flanking lysine	0.2222
p.R737Q	TCGA-CM-6677	COAD	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	TCGA-K1-A6RV	SARC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	DO8570	COAD	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	DO220197	SARC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	SIDM01394	Kidney Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.R737Q	ACH-000907	Kidney Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7329
p.P735Q	TCGA-D3-A2JO	SKCM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.P735Q	DO47619	SKCM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.P735T	TCGA-DX-A1KX	SARC	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.P735T	DO219946	SARC	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.V990A	TCGA-FI-A2D5	UCEC	TCGA	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation rewiring degron network	0.0833
p.V990A	TCGA-FI-A2D5	UCEC	TCGA	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation rewiring degron network	0.0833
p.V990A	DO41331	UCEC	ICGC	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation rewiring degron network	0.0833
p.V990A	DO41331	UCEC	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation rewiring degron network	0.0833
p.R752K	TCGA-FS-A1ZK	SKCM	TCGA	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.R752K	DO37474	SKCM	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.P1101T	DO229019	LICA	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.3056
p.Q967K	DO229015	LICA	ICGC	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation rewiring degron network	0.0833
p.Q967K	DO229015	LICA	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation rewiring degron network	0.1111
p.L1099I	DO229034	LICA	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.6063
p.G744S	DO45169	LIRI	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.5882
p.E1090Q	DO229172	LMS	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.V974A	DO222702	MELA	ICGC	LVLYGE	LIG_APCC_ABBA_1	976:981	Mutation rewiring degron network	0.2778
p.V974A	DO222702	MELA	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation rewiring degron network	0.3056
p.R749Q	DO227832	PBCA	ICGC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.R975T	SIDM01048	Plasma Cell Myeloma	GDSC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation altering degron motif	0.7876
p.R975T	ACH-000821	Myeloma	CCLE	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation altering degron motif	0.7876
p.R975T	EJM	haematopoietic and lymphoid tissue	COSMIC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	975:981	Mutation altering degron motif	0.7876
p.V731I	SIDM00627	Cervical Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM00025	Head and Neck Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM01002	Breast Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM00474	Ovarian Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM01148	Plasma Cell Myeloma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM00853	Other Sarcomas	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM00752	Non-Cancerous	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V731I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.P1101S	SIDM01175	Other Sarcomas	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.3056
p.P1101S	ACH-002309	Sarcoma	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.3056
p.P1101S	SW684	soft tissue	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.3056
p.R1093K	SIDM00281	Other Solid Cancers	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.7237
p.R1093K	ACH-002100	Skin Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.7237
p.R1093K	DJM-1	skin	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.7237
p.E1102D	SIDM00150	Colorectal Carcinoma	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.E1102D	ACH-000969	Colon/Colorectal Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.E1102D	KM12	large intestine	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.L740P	SIDM01612	Endometrial Carcinoma	GDSC	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7582
p.L740P	ACH-000946	Endometrial/Uterine Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7582
p.A736T	ACH-000958	Colon/Colorectal Cancer	CCLE	ARFQLQYMG	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6028
p.W1083C	ACH-001407	Bladder Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX60

UniProt ID: Q8IY21

Entrez ID: 55601

Protein name: Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DDX60 in