DegronMD

Uniprot ID: Q8IY21

Source protein: Probable ATP-dependent RNA helicase DDX60

Source gene: DDX60

Class: DEG_APCC_DBOX_1

Location: 1092:1100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6487

ASA_SCORE: 57.2667

COIL: 0.2143

CONS_SCORE: 0.3786

DSS_SCORE: 0.346

HELIX: 0.7762

FCONS_SCORE: 1.2319

RIG_SCORE: 0.7929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1105F	TCGA-34-8454	LUSC	TCGA	ARMVLQNLS	DEG_APCC_DBOX_1	0.1944
p.L1105F	DO50094	LUSC	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	0.1944
p.E1108K	TCGA-3N-A9WD	SKCM	TCGA	ARMVLQNLS	DEG_APCC_DBOX_1	0.1111
p.E1108K	DO51235	SKCM	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	0.1111
p.P1101T	DO229019	LICA	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	0.3056
p.L1099I	DO229034	LICA	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	0.6063
p.E1090Q	DO229172	LMS	ICGC	ARMVLQNLS	DEG_APCC_DBOX_1	0.2778
p.P1101S	SIDM01175	Other Sarcomas	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	0.3056
p.P1101S	ACH-002309	Sarcoma	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	0.3056
p.P1101S	SW684	soft_tissue	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	0.3056
p.R1093K	SIDM00281	Other Solid Cancers	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	0.7237
p.R1093K	ACH-002100	Skin Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	0.7237
p.R1093K	DJM-1	skin	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	0.7237
p.E1102D	SIDM00150	Colorectal Carcinoma	GDSC	ARMVLQNLS	DEG_APCC_DBOX_1	0.2778
p.E1102D	ACH-000969	Colon/Colorectal Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	0.2778
p.E1102D	KM12	large_intestine	COSMIC	ARMVLQNLS	DEG_APCC_DBOX_1	0.2778
p.W1083C	ACH-001407	Bladder Cancer	CCLE	ARMVLQNLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY21	Probable ATP-dependent RNA helicase DDX60	DEG_APCC_DBOX_1	1092:1100	ARMVLQNLS	APC,CDC20,FZR1	0.6487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons