DegronMD

Uniprot ID: Q8IY21

Source protein: Probable ATP-dependent RNA helicase DDX60

Source gene: DDX60

Class: LIG_APCC_ABBA_1

Location: 976:981

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8341

ASA_SCORE: 55.9833

COIL: 0.4955

CONS_SCORE: 0.435

DSS_SCORE: 0.1184

HELIX: 0.0888

FCONS_SCORE: 1.2035

RIG_SCORE: 0.8926

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V977L	TCGA-55-6979	LUAD	TCGA	LVLYGE	LIG_APCC_ABBA_1	0.5654
p.V977L	DO24110	LUAD	ICGC	LVLYGE	LIG_APCC_ABBA_1	0.5654
p.V990A	TCGA-FI-A2D5	UCEC	TCGA	LVLYGE	LIG_APCC_ABBA_1	0.0833
p.V990A	DO41331	UCEC	ICGC	LVLYGE	LIG_APCC_ABBA_1	0.0833
p.Q967K	DO229015	LICA	ICGC	LVLYGE	LIG_APCC_ABBA_1	0.0833
p.V974A	DO222702	MELA	ICGC	LVLYGE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY21	Probable ATP-dependent RNA helicase DDX60	LIG_APCC_ABBA_1	976:981	LVLYGE	APC,CDC20,FZR1	0.8341	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons