DegronMD

Uniprot ID: Q8IY21

Source protein: Probable ATP-dependent RNA helicase DDX60

Source gene: DDX60

Class: LIG_APCC_ABBAyCdc20_2

Location: 975:981

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6013

ASA_SCORE: 62.6286

COIL: 0.4727

CONS_SCORE: 0.4247

DSS_SCORE: 0.1166

HELIX: 0.086

FCONS_SCORE: 1.2195

RIG_SCORE: 0.899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V977L	TCGA-55-6979	LUAD	TCGA	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V977L	DO24110	LUAD	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V990A	TCGA-FI-A2D5	UCEC	TCGA	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V990A	DO41331	UCEC	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q967K	DO229015	LICA	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V974A	DO222702	MELA	ICGC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R975T	SIDM01048	Plasma Cell Myeloma	GDSC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R975T	ACH-000821	Myeloma	CCLE	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R975T	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	RLVLYGE	LIG_APCC_ABBAyCdc20_2	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY21	Probable ATP-dependent RNA helicase DDX60	LIG_APCC_ABBAyCdc20_2	975:981	RLVLYGE	APC,CDC20,FZR1	0.6013	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons