DegronMD

Uniprot ID: Q86W26

Source protein: NACHT, LRR and PYD domains-containing protein 10

Source gene: NLRP10

Class: DEG_APCC_DBOX_1

Location: 45:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6821

ASA_SCORE: 79.1222

COIL: 0.7583

CONS_SCORE: 0.5528

DSS_SCORE: 0.2022

HELIX: 0.2008

FCONS_SCORE: 1.1249

RIG_SCORE: 0.7784

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R46I	TCGA-06-5416	GBM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.8102
p.R46I	DO10880	GBM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.8102
p.T36I	TCGA-18-3409	LUSC	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36I	TCGA-D3-A8GP	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36I	TCGA-FS-A1ZQ	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36I	DO26444	LUSC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36I	DO37442	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36I	DO51244	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.E48K	TCGA-24-2290	OV	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.591
p.E48K	TCGA-BF-AAP0	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.591
p.E48K	DO30090	OV	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.591
p.E48K	DO219462	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.591
p.S63L	TCGA-DA-A1I7	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.0556
p.S63L	DO37951	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.0556
p.S63P	TCGA-FI-A2D5	UCEC	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	0.0556
p.S63P	DO41331	UCEC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.0556
p.E59Q	DO1094	BRCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.1667
p.P54L	DO224664	COCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.3056
p.D56G	DO234183	ESAD	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.25
p.G51D	DO233944	GACA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.6087
p.P42H	DO231124	LUSC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.25
p.M35I	DO229229	THCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	0.0556
p.S38F	SIDM01291	Esophageal Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.5833
p.E50Q	SIDM01174	Cervical Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.5633
p.E50Q	ACH-001402	Cervical Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.5633
p.E50Q	SW756	cervix	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	0.5633
p.T36A	SIDM00193	Colorectal Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36A	ACH-000991	Colon/Colorectal Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.T36A	SNU-81	large_intestine	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	0.5278
p.A58E	SIDM00998	Glioblastoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.A58E	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.A58E	ACH-000137	Brain Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.A58E	ACH-000980	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.A58E	NCI-H1155	lung	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.A58E	8-MG-BA	central_nervous_system	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	0.1944
p.G51C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	0.6489
p.G51C	ACH-000888	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.6489
p.G51C	NCI-H1793	lung	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	0.6489
p.P54Q	ACH-000737	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARGELEGLI

Degron related mutations and impact score

Drug responses associated with NLRP10 mutations

All proteins holding degron of ARGELEGLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W26	NACHT, LRR and PYD domains-containing protein 10	DEG_APCC_DBOX_1	45:53	ARGELEGLI	APC,CDC20,FZR1	0.6821	More...