DegronMD - Q86W26(NLRP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R46I	TCGA-06-5416	GBM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.8102
p.R46I	DO10880	GBM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.8102
p.T36I	TCGA-18-3409	LUSC	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36I	TCGA-D3-A8GP	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36I	TCGA-FS-A1ZQ	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36I	DO26444	LUSC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36I	DO37442	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36I	DO51244	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.E48K	TCGA-24-2290	OV	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.591
p.E48K	TCGA-BF-AAP0	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.591
p.E48K	DO30090	OV	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.591
p.E48K	DO219462	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.591
p.G159V	TCGA-51-4079	LUSC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.7532
p.G159V	DO26437	LUSC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.7532
p.L164M	TCGA-55-A490	LUAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.3056
p.L164M	DO24596	LUAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.3056
p.V152A	TCGA-AJ-A8CW	UCEC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1944
p.V152A	DO52400	UCEC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1944
p.A165V	TCGA-B5-A3FA	UCEC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.2778
p.A165V	DO52402	UCEC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.2778
p.T151M	TCGA-CG-5726	STAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1667
p.T151M	DO38483	STAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1667
p.D157N	TCGA-D3-A8GI	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.6932
p.D157N	DO50284	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.6932
p.E160K	TCGA-D3-A8GQ	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.E160K	DO220891	MELA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.E160K	DO51246	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.E160K	SIDM00140	Melanoma	GDSC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.E160K	ACH-000968	Skin Cancer	CCLE	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.E160K	COLO-792	skin	COSMIC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.591
p.S63L	TCGA-DA-A1I7	SKCM	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.S63L	DO37951	SKCM	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.P162L	TCGA-EE-A3J7	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.6471
p.P162L	DO48770	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation altering degron motif	0.6471
p.P166A	TCGA-F1-6177	STAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.25
p.P166A	DO38727	STAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.25
p.S63P	TCGA-FI-A2D5	UCEC	TCGA	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.S63P	DO41331	UCEC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.S149F	TCGA-MP-A4T4	LUAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1111
p.S149F	DO45357	LUAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1111
p.A154T	TCGA-ND-A4WC	UCS	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.25
p.E59Q	DO1094	BRCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1667
p.P54L	DO224664	COCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056
p.D56G	DO234183	ESAD	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.25
p.L147P	DO233170	GACA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.0556
p.G51D	DO233944	GACA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6087
p.Q172H	DO231022	LUSC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.0833
p.P42H	DO231124	LUSC	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.25
p.V150A	DO232224	PBCA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.1389
p.M35I	DO229229	THCA	ICGC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.S38F	SIDM01291	Esophageal Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5833
p.E50Q	SIDM01174	Cervical Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5633
p.E50Q	ACH-001402	Cervical Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5633
p.E50Q	SW756	cervix	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5633
p.T36A	SIDM00193	Colorectal Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36A	ACH-000991	Colon/Colorectal Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.T36A	SNU-81	large intestine	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation blocking phosphorylation signal	0.5278
p.A58E	SIDM00998	Glioblastoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.A58E	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.A58E	ACH-000137	Brain Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.A58E	ACH-000980	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.A58E	NCI-H1155	lung	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.A58E	8-MG-BA	central nervous system	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.G51C	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6489
p.G51C	ACH-000888	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6489
p.G51C	NCI-H1793	lung	COSMIC	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6489
p.E153K	SIDM01588	Endometrial Carcinoma	GDSC	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.2222
p.E153K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGEKPS	DEG_SCF_TRCP1_1	157:163	Mutation rewiring degron network	0.2222
p.P54Q	ACH-000737	Lung Cancer	CCLE	ARGELEGLI	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLRP10

UniProt ID: Q86W26

Entrez ID: 338322

Protein name: NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLRP10 in