DegronMD

Uniprot ID: Q86W26

Source protein: NACHT, LRR and PYD domains-containing protein 10

Source gene: NLRP10

Class: DEG_SCF_TRCP1_1

Location: 157:163

E3 ligase: BTRC

DEGRON score: 0.8546

ASA_SCORE: 90.4571

COIL: 0.924

CONS_SCORE: 0.4594

DSS_SCORE: 0.3485

HELIX: 0.036

FCONS_SCORE: 0.7957

RIG_SCORE: 0.7045

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G159V	TCGA-51-4079	LUSC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.7532
p.G159V	DO26437	LUSC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.7532
p.L164M	TCGA-55-A490	LUAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.3056
p.L164M	DO24596	LUAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.3056
p.V152A	TCGA-AJ-A8CW	UCEC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.1944
p.V152A	DO52400	UCEC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.1944
p.A165V	TCGA-B5-A3FA	UCEC	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.2778
p.A165V	DO52402	UCEC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.2778
p.T151M	TCGA-CG-5726	STAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.1667
p.T151M	DO38483	STAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.1667
p.D157N	TCGA-D3-A8GI	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.6932
p.D157N	DO50284	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.6932
p.E160K	TCGA-D3-A8GQ	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.E160K	DO220891	MELA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.E160K	DO51246	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.E160K	SIDM00140	Melanoma	GDSC	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.E160K	ACH-000968	Skin Cancer	CCLE	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.E160K	COLO-792	skin	COSMIC	DSGEKPS	DEG_SCF_TRCP1_1	0.591
p.P162L	TCGA-EE-A3J7	SKCM	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.6471
p.P162L	DO48770	SKCM	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.6471
p.P166A	TCGA-F1-6177	STAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.25
p.P166A	DO38727	STAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.25
p.S149F	TCGA-MP-A4T4	LUAD	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.1111
p.S149F	DO45357	LUAD	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.1111
p.A154T	TCGA-ND-A4WC	UCS	TCGA	DSGEKPS	DEG_SCF_TRCP1_1	0.25
p.L147P	DO233170	GACA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.0556
p.Q172H	DO231022	LUSC	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.0833
p.V150A	DO232224	PBCA	ICGC	DSGEKPS	DEG_SCF_TRCP1_1	0.1389
p.E153K	SIDM01588	Endometrial Carcinoma	GDSC	DSGEKPS	DEG_SCF_TRCP1_1	0.2222
p.E153K	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGEKPS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGEKPS

Degron related mutations and impact score

Drug responses associated with NLRP10 mutations

All proteins holding degron of DSGEKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W26	NACHT, LRR and PYD domains-containing protein 10	DEG_SCF_TRCP1_1	157:163	DSGEKPS	BTRC	0.8546	More...