DegronMD

Uniprot ID: Q96C12

Source protein: Armadillo repeat-containing protein 5

Source gene: ARMC5

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5213

ASA_SCORE: 51.9778

COIL: 0.3171

CONS_SCORE: 0.5229

DSS_SCORE: 0.2239

HELIX: 0.6759

FCONS_SCORE: 1.2703

RIG_SCORE: 0.7974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G57E	TCGA-EB-A551	SKCM	TCGA	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.G57E	DO47453	SKCM	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.A53S	DO5920	BRCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.5
p.G66E	DO224661	COCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.6087
p.R75G	DO233289	GACA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.2222
p.V57L	DO229028	LICA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.G55V	DO229008	LICA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1111
p.E77Q	DO23166	LINC	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.AG55AR	DO220891	MELA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0
p.G56R	DO220891	MELA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1389
p.L59F	DO46372	OV	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.2222
p.L59P	DO46372	OV	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.2222
p.G57R	DO229479	SKCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.G57R	DO218900	SKCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.1667
p.A80V	DO229268	THCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.0833
p.E59K	DO229221	THCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.2222
p.L59I	DO41235	UCEC	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C12	Armadillo repeat-containing protein 5	DEG_APCC_DBOX_1	63:71	ARGGLRPLL	APC,CDC20,FZR1	0.5213	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons