DegronMD - Q96C12(ARMC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R857H	TCGA-A5-A0G1	UCEC	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0833
p.F842L	TCGA-D8-A1J8	BRCA	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.587
p.G57E	TCGA-EB-A551	SKCM	TCGA	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.G57E	DO47453	SKCM	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.I858F	TCGA-UB-A7MB	LIHC	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0556
p.A53S	DO5920	BRCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation blocking ubiquitination signal	0.5
p.G66E	DO224661	COCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6087
p.R75G	DO233289	GACA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.V57L	DO229028	LICA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.G55V	DO229008	LICA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.E77Q	DO23166	LINC	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.AG55AR	DO220891	MELA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0
p.G56R	DO220891	MELA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.L59F	DO46372	OV	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.L59P	DO46372	OV	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.G57R	DO229479	SKCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.G57R	DO218900	SKCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.A80V	DO229268	THCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.E59K	DO229221	THCA	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.L59I	DO41235	UCEC	ICGC	ARGGLRPLL	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.L855H	SIDM00189	Melanoma	GDSC	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1389
p.L855H	CP67-MEL	skin	COSMIC	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1389
p.G840R	ACH-000935	Colon/Colorectal Cancer	CCLE	GRFLLPGLE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.6457

Kaplan plot for ARMC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARMC5

UniProt ID: Q96C12

Entrez ID: 79798

Protein name: Armadillo repeat-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARMC5 in