DegronMD

Uniprot ID: Q96C12

Source protein: Armadillo repeat-containing protein 5

Source gene: ARMC5

Class: DEG_APCC_DBOX_1

Location: 840:848

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5885

ASA_SCORE: 34.4333

COIL: 0.3683

CONS_SCORE: 0.5873

DSS_SCORE: 0.4357

HELIX: 0.6277

FCONS_SCORE: 1.4604

RIG_SCORE: 0.7646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R857H	TCGA-A5-A0G1	UCEC	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	0.0833
p.F842L	TCGA-D8-A1J8	BRCA	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	0.587
p.I858F	TCGA-UB-A7MB	LIHC	TCGA	GRFLLPGLE	DEG_APCC_DBOX_1	0.0556
p.L855H	SIDM00189	Melanoma	GDSC	GRFLLPGLE	DEG_APCC_DBOX_1	0.1389
p.L855H	CP67-MEL	skin	COSMIC	GRFLLPGLE	DEG_APCC_DBOX_1	0.1389
p.G840R	ACH-000935	Colon/Colorectal Cancer	CCLE	GRFLLPGLE	DEG_APCC_DBOX_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C12	Armadillo repeat-containing protein 5	DEG_APCC_DBOX_1	840:848	GRFLLPGLE	APC,CDC20,FZR1	0.5885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons