DegronMD

Uniprot ID: Q8N0Z3

Source protein: Spindle and centriole-associated protein 1

Source gene: SPICE1

Class: DEG_APCC_DBOX_1

Location: 741:749

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7606

ASA_SCORE: 71.1444

COIL: 0.2393

CONS_SCORE: 0.5962

DSS_SCORE: 0.3038

HELIX: 0.7493

FCONS_SCORE: 1.0625

RIG_SCORE: 0.7984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E740Q	TCGA-4Z-AA7M	BLCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	0.3056
p.E740Q	DO218976	BLCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.3056
p.Q747H	TCGA-A8-A06X	BRCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	0.647
p.Q747H	DO5074	BRCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.647
p.E733K	TCGA-D8-A27G	BRCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	0.1111
p.E733K	DO5465	BRCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.1111
p.A741V	TCGA-EB-A3Y6	SKCM	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	0.5825
p.A741V	DO38081	SKCM	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.5825
p.R742C	TCGA-GF-A6C9	SKCM	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	0.8301
p.R742C	DO51254	SKCM	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.8301
p.L748F	DO233727	GACA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	0.6981
p.R736Q	SIDM00534	Colorectal Carcinoma	GDSC	ARGKLLQLI	DEG_APCC_DBOX_1	0.1944
p.R736Q	ACH-000986	Colon/Colorectal Cancer	CCLE	ARGKLLQLI	DEG_APCC_DBOX_1	0.1944
p.R736Q	HT-115	large_intestine	COSMIC	ARGKLLQLI	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0Z3	Spindle and centriole-associated protein 1	DEG_APCC_DBOX_1	741:749	ARGKLLQLI	APC,CDC20,FZR1	0.7606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons