DegronMD - Q8N0Z3(SPICE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I228T	TCGA-4R-AA8I	LIHC	TCGA	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.I228T	DO49657	LIHC	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.E740Q	TCGA-4Z-AA7M	BLCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.E740Q	DO218976	BLCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.Q747H	TCGA-A8-A06X	BRCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.647
p.Q747H	DO5074	BRCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.647
p.T239M	TCGA-AX-A0J1	UCEC	TCGA	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.T239M	TCGA-CG-4436	STAD	TCGA	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.T239M	TCGA-CM-4743	COAD	TCGA	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.T239M	DO8103	COAD	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.T239M	DO38320	STAD	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.T239M	DO41199	UCEC	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.8534
p.E733K	TCGA-D8-A27G	BRCA	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1111
p.E733K	DO5465	BRCA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1111
p.A741V	TCGA-EB-A3Y6	SKCM	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.5825
p.A741V	DO38081	SKCM	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.5825
p.R742C	TCGA-GF-A6C9	SKCM	TCGA	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.8301
p.R742C	DO51254	SKCM	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.8301
p.P236S	TCGA-YG-AA3O	SKCM	TCGA	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.6752
p.P236S	DO51299	SKCM	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.6752
p.E248K	DO223026	ESCA	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0833
p.E248K	SIDM01228	Melanoma	GDSC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0833
p.E248K	ACH-000931	Skin Cancer	CCLE	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0833
p.E248K	ACH-001024	Skin Cancer	CCLE	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0833
p.E248K	CHL-1	skin	COSMIC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0833
p.L748F	DO233727	GACA	ICGC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.6981
p.Q226K	DO229022	LICA	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1111
p.S245L	DO50913	LICA	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.I228M	DO228176	PBCA	ICGC	ITPPGT	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.R736Q	SIDM00534	Colorectal Carcinoma	GDSC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1944
p.R736Q	ACH-000986	Colon/Colorectal Cancer	CCLE	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1944
p.R736Q	HT-115	large intestine	COSMIC	ARGKLLQLI	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1944

Kaplan plot for SPICE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPICE1

UniProt ID: Q8N0Z3

Entrez ID: 152185

Protein name: Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPICE1 in