DegronMD

Uniprot ID: Q8N0Z3

Source protein: Spindle and centriole-associated protein 1

Source gene: SPICE1

Class: DEG_SCF_FBW7_1

Location: 234:239

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 84.1667

COIL: 0.9598

CONS_SCORE: 0.3818

DSS_SCORE: 0.6028

HELIX: 0.0088

FCONS_SCORE: 0.9057

RIG_SCORE: 0.6276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I228T	TCGA-4R-AA8I	LIHC	TCGA	ITPPGT	DEG_SCF_FBW7_1	0.1667
p.I228T	DO49657	LIHC	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.1667
p.T239M	TCGA-AX-A0J1	UCEC	TCGA	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.T239M	TCGA-CG-4436	STAD	TCGA	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.T239M	TCGA-CM-4743	COAD	TCGA	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.T239M	DO8103	COAD	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.T239M	DO38320	STAD	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.T239M	DO41199	UCEC	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.8534
p.P236S	TCGA-YG-AA3O	SKCM	TCGA	ITPPGT	DEG_SCF_FBW7_1	0.6752
p.P236S	DO51299	SKCM	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.6752
p.E248K	DO223026	ESCA	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.0833
p.E248K	SIDM01228	Melanoma	GDSC	ITPPGT	DEG_SCF_FBW7_1	0.0833
p.E248K	ACH-000931	Skin Cancer	CCLE	ITPPGT	DEG_SCF_FBW7_1	0.0833
p.E248K	ACH-001024	Skin Cancer	CCLE	ITPPGT	DEG_SCF_FBW7_1	0.0833
p.E248K	CHL-1	skin	COSMIC	ITPPGT	DEG_SCF_FBW7_1	0.0833
p.Q226K	DO229022	LICA	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.1111
p.S245L	DO50913	LICA	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.1667
p.I228M	DO228176	PBCA	ICGC	ITPPGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0Z3	Spindle and centriole-associated protein 1	DEG_SCF_FBW7_1	234:239	ITPPGT	FBXW7	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons