DegronMD

Uniprot ID: Q9UEE5

Source protein: Serine/threonine-protein kinase 17A

Source gene: STK17A

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 76.9778

COIL: 0.5213

CONS_SCORE: 0.3453

DSS_SCORE: 0.5523

HELIX: 0.111

FCONS_SCORE: 1.4272

RIG_SCORE: 0.7581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I46V	TCGA-2K-A9WE	KIRP	TCGA	ARGLLTEIR	DEG_APCC_DBOX_1	0.5965
p.I46V	DO51550	KIRP	ICGC	ARGLLTEIR	DEG_APCC_DBOX_1	0.5965
p.P54S	DO228824	MALY	ICGC	ARGLLTEIR	DEG_APCC_DBOX_1	0.1389
p.P54S	ACH-000601	Pancreatic Cancer	CCLE	ARGLLTEIR	DEG_APCC_DBOX_1	0.1389
p.G29R	SIDM00672	Hepatocellular Carcinoma	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.G29R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.G29R	SIDM01076	B-Lymphoblastic Leukemia	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.G29R	SIDM00954	Breast Carcinoma	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.G29R	SIDM00863	Burkitt's Lymphoma	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.G29R	SIDM00760	Small Cell Lung Carcinoma	GDSC	ARGLLTEIR	DEG_APCC_DBOX_1	0.0556
p.P37T	ACH-000378	Lung Cancer	CCLE	ARGLLTEIR	DEG_APCC_DBOX_1	0.2778
p.P37H	ACH-000378	Lung Cancer	CCLE	ARGLLTEIR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UEE5	Serine/threonine-protein kinase 17A	DEG_APCC_DBOX_1	39:47	ARGLLTEIR	APC,CDC20,FZR1	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons