DegronMD

Uniprot ID: O00482

Source protein: Nuclear receptor subfamily 5 group A member 2

Source gene: NR5A2

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5508

ASA_SCORE: 91.0444

COIL: 0.8219

CONS_SCORE: 0.4058

DSS_SCORE: 0.4833

HELIX: 0.0431

FCONS_SCORE: 1.0503

RIG_SCORE: 0.7452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S31F	TCGA-FW-A3R5	SKCM	TCGA	ARGRLVMLP	DEG_APCC_DBOX_1	0.6667
p.S31F	DO37406	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.6667
p.R28P	TCGA-OR-A5K6	ACC	TCGA	ARGRLVMLP	DEG_APCC_DBOX_1	0.1389
p.E34K	DO44381	CESC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.3056
p.E34K	DO6254	CESC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.3056
p.D35H	DO23555	LUAD	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.7688
p.T47K	DO49147	PACA	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.2222
p.G53W	DO37643	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.0556
p.G53W	DO37810	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.0556
p.P41L	DO38153	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.7582
p.Y52C	DO41020	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.0833
p.D35N	DO41235	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.6932
p.S48P	DO42673	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1944
p.G30R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1944
p.G30R	ACH-000929	Lung Cancer	CCLE	ARGRLVMLP	DEG_APCC_DBOX_1	0.1944
p.G30R	NCI-H2110	lung	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1944
p.R28Q	SIDM00522	Small Cell Lung Carcinoma	GDSC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1389
p.R28Q	ACH-000749	Lung Cancer	CCLE	ARGRLVMLP	DEG_APCC_DBOX_1	0.1389
p.R28Q	DMS-273	lung	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1389
p.I51M	HCC1569	breast	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1111
p.G49W	LS-1034	large_intestine	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1667
p.L29V	MZ2-MEL	skin	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_APCC_DBOX_1	35:43	ARGRLVMLP	APC,CDC20,FZR1	0.5508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons