DegronMD - O00482(NR5A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D275N	TCGA-37-4135	LUSC	TCGA	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.5821
p.D275N	DO26806	LUSC	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.5821
p.P281H	TCGA-69-7973	LUAD	TCGA	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.7694
p.P281H	DO23870	LUAD	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.7694
p.S31F	TCGA-FW-A3R5	SKCM	TCGA	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation blocking phosphorylation signal	0.6667
p.S31F	DO37406	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation blocking phosphorylation signal	0.6667
p.R28P	TCGA-OR-A5K6	ACC	TCGA	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.A268V	TCGA-VQ-A91D	STAD	TCGA	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.A268V	TCGA-VQ-A91D	STAD	TCGA	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.1389
p.A268V	DO51783	STAD	ICGC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.A268V	DO51783	STAD	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.1389
p.E272Q	TCGA-ZF-A9RD	BLCA	TCGA	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.E272Q	TCGA-ZF-A9RD	BLCA	TCGA	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.25
p.E34K	DO44381	CESC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.E34K	DO6254	CESC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.R267W	DO233726	GACA	ICGC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.R267W	DO233726	GACA	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.1111
p.D268G	DO48733	LIRI	ICGC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.D268G	DO48733	LIRI	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.1389
p.E269G	DO48733	LIRI	ICGC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.E269G	DO48733	LIRI	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.1667
p.D35H	DO23555	LUAD	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7688
p.Q281K	DO26830	LUSC	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.6944
p.T47K	DO49147	PACA	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2222
p.E266K	DO228017	SKCA	ICGC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.E266K	DO228017	SKCA	ICGC	DPYTSSP	CBL_PTK	275:281	Mutation rewiring degron network	0.0833
p.G53W	DO37643	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.G53W	DO37810	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.P41L	DO38153	SKCM	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7582
p.Y52C	DO41020	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.D35N	DO41235	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6932
p.S48P	DO42673	UCEC	ICGC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.G30R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.G30R	ACH-000929	Lung Cancer	CCLE	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.G30R	NCI-H2110	lung	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R28Q	SIDM00522	Small Cell Lung Carcinoma	GDSC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.R28Q	ACH-000749	Lung Cancer	CCLE	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.R28Q	DMS-273	lung	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.Q279L	QGP-1	pancreas	COSMIC	PYTSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7765
p.Q279L	QGP-1	pancreas	COSMIC	DPYTSSP	CBL_PTK	275:281	Mutation altering degron motif	0.7765
p.I51M	HCC1569	breast	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.G49W	LS-1034	large intestine	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.L29V	MZ2-MEL	skin	COSMIC	ARGRLVMLP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667

Kaplan plot for NR5A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR5A2

UniProt ID: O00482

Entrez ID: 2494

Protein name: Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR5A2 in