DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DPYTSSP
Uniprot ID:
O00482
Source protein:
Nuclear receptor subfamily 5 group A member 2
Source gene:
NR5A2
Class:
CBL_PTK
Location:
275:281
E3 ligase:
CBL
DEGRON score:
0.8404
ASA_SCORE:
56.0429
COIL:
0.8667
CONS_SCORE:
0.5148
DSS_SCORE:
0.4315
HELIX:
0.0706
FCONS_SCORE:
1.2772
RIG_SCORE:
0.6852
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D275N
TCGA-37-4135
LUSC
TCGA
DPYTSSP
CBL_PTK
0.5821
p.D275N
DO26806
LUSC
ICGC
DPYTSSP
CBL_PTK
0.5821
p.P281H
TCGA-69-7973
LUAD
TCGA
DPYTSSP
CBL_PTK
0.7694
p.P281H
DO23870
LUAD
ICGC
DPYTSSP
CBL_PTK
0.7694
p.A268V
TCGA-VQ-A91D
STAD
TCGA
DPYTSSP
CBL_PTK
0.1389
p.A268V
DO51783
STAD
ICGC
DPYTSSP
CBL_PTK
0.1389
p.E272Q
TCGA-ZF-A9RD
BLCA
TCGA
DPYTSSP
CBL_PTK
0.25
p.R267W
DO233726
GACA
ICGC
DPYTSSP
CBL_PTK
0.1111
p.D268G
DO48733
LIRI
ICGC
DPYTSSP
CBL_PTK
0.1389
p.E269G
DO48733
LIRI
ICGC
DPYTSSP
CBL_PTK
0.1667
p.Q281K
DO26830
LUSC
ICGC
DPYTSSP
CBL_PTK
0.6944
p.E266K
DO228017
SKCA
ICGC
DPYTSSP
CBL_PTK
0.0833
p.Q279L
QGP-1
pancreas
COSMIC
DPYTSSP
CBL_PTK
0.7765
Drug responses associated with NR5A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPYTSSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00482
Nuclear receptor subfamily 5 group A member 2
CBL_PTK
275:281
DPYTSSP
CBL
0.8404
More...
