DegronMD

Uniprot ID: O00482

Source protein: Nuclear receptor subfamily 5 group A member 2

Source gene: NR5A2

Class: DEG_SPOP_SBC_1

Location: 276:280

E3 ligase: SPOP

DEGRON score: 0.8022

ASA_SCORE: 55.52

COIL: 0.8596

CONS_SCORE: 0.5078

DSS_SCORE: 0.4186

HELIX: 0.068

FCONS_SCORE: 1.2228

RIG_SCORE: 0.6813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A268V	TCGA-VQ-A91D	STAD	TCGA	PYTSS	DEG_SPOP_SBC_1	0.1111
p.A268V	DO51783	STAD	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1111
p.E272Q	TCGA-ZF-A9RD	BLCA	TCGA	PYTSS	DEG_SPOP_SBC_1	0.2222
p.R267W	DO233726	GACA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.0833
p.D268G	DO48733	LIRI	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1111
p.E269G	DO48733	LIRI	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1389
p.E266K	DO228017	SKCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.0556
p.Q279L	QGP-1	pancreas	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.7765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_SPOP_SBC_1	276:280	PYTSS	SPOP	0.8022	More...
O75925	E3 SUMO-protein ligase PIAS1	DEG_SPOP_SBC_1	582:586	PYTSS	SPOP	0.8855	More...
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SPOP_SBC_1	160:164	PYTSS	SPOP	0.596	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	1531:1535	PYTSS	SPOP	0.9971	More...
A6NJB7	Proline-rich protein 19	DEG_SPOP_SBC_1	242:246	PYTSS	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons