DegronMD

Uniprot ID: O75925

Source protein: E3 SUMO-protein ligase PIAS1

Source gene: PIAS1

Class: DEG_SPOP_SBC_1

Location: 582:586

E3 ligase: SPOP

DEGRON score: 0.8855

ASA_SCORE: 74.48

COIL: 0.8872

CONS_SCORE: 0.2989

DSS_SCORE: 0.2393

HELIX: 0.0682

FCONS_SCORE: 1.1766

RIG_SCORE: 0.7858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F589L	TCGA-BB-A5HY	HNSC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.25
p.F589L	DO218979	HNSC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.25
p.D573Y	TCGA-IB-7651	PAAD	TCGA	PYTSS	DEG_SPOP_SBC_1	0.0833
p.D573Y	DO46657	PAAD	ICGC	PYTSS	DEG_SPOP_SBC_1	0.0833
p.F581L	DO1110	BRCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.A595S	DO229029	LICA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.0833
p.H576Q	ACH-001955	Bone Cancer	CCLE	PYTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_SPOP_SBC_1	276:280	PYTSS	SPOP	0.8022	More...
O75925	E3 SUMO-protein ligase PIAS1	DEG_SPOP_SBC_1	582:586	PYTSS	SPOP	0.8855	More...
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SPOP_SBC_1	160:164	PYTSS	SPOP	0.596	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	1531:1535	PYTSS	SPOP	0.9971	More...
A6NJB7	Proline-rich protein 19	DEG_SPOP_SBC_1	242:246	PYTSS	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons