DegronMD

Uniprot ID: A6NJB7

Source protein: Proline-rich protein 19

Source gene: PRR19

Class: DEG_SPOP_SBC_1

Location: 242:246

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 76

COIL: 0.9032

CONS_SCORE: 0.5357

DSS_SCORE: 0.5987

HELIX: 0.0276

FCONS_SCORE: 1.1912

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F237L	TCGA-CI-6620	READ	TCGA	PYTSS	DEG_SPOP_SBC_1	0.1944
p.F237L	DO36825	READ	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1944
p.A250G	SIDM01318	Hepatocellular Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	0.2222
p.A250G	ACH-001318	Liver Cancer	CCLE	PYTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_SPOP_SBC_1	276:280	PYTSS	SPOP	0.8022	More...
O75925	E3 SUMO-protein ligase PIAS1	DEG_SPOP_SBC_1	582:586	PYTSS	SPOP	0.8855	More...
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SPOP_SBC_1	160:164	PYTSS	SPOP	0.596	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	1531:1535	PYTSS	SPOP	0.9971	More...
A6NJB7	Proline-rich protein 19	DEG_SPOP_SBC_1	242:246	PYTSS	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons