DegronMD - P28906(CD34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E326K	TCGA-04-1331	OV	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	TCGA-AP-A0LM	UCEC	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	TCGA-C8-A26Y	BRCA	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	TCGA-PE-A5DE	BRCA	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	DO1273	BRCA	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	DO219643	BRCA	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	DO28119	OV	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	DO43306	UCEC	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.E326K	ACH-001518	Endometrial/Uterine Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1389
p.T155I	TCGA-17-Z017	LUAD	TCGA	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1944
p.P124T	TCGA-55-7907	LUAD	TCGA	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.25
p.P124T	DO25396	LUAD	ICGC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.25
p.G335V	TCGA-55-8089	LUAD	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation altering degron motif	0.6421
p.G335V	DO23690	LUAD	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation altering degron motif	0.6421
p.G342V	TCGA-56-6546	LUSC	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation altering degron motif	0.6421
p.G342V	DO26542	LUSC	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation altering degron motif	0.6421
p.I117T	TCGA-AJ-A5DW	UCEC	TCGA	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.0556
p.I117T	DO50075	UCEC	ICGC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.0556
p.S165Y	TCGA-BK-A6W3	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.S165Y	DO222762	COCA	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.S165Y	DO50076	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.S165Y	SIDM01588	Endometrial Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.S165Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.P347L	TCGA-CF-A27C	BLCA	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.2222
p.P347L	DO828	BLCA	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.2222
p.P157L	TCGA-CV-6956	HNSC	TCGA	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.P157L	DO15815	HNSC	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.P347H	TCGA-D9-A1X3	SKCM	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.2222
p.P347T	TCGA-EE-A29E	SKCM	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.2222
p.T331A	TCGA-F7-A624	HNSC	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation blocking phosphorylation signal	0.7222
p.S346Y	TCGA-HE-7129	KIRP	TCGA	NGGGQGYSSGP	CBL_PTK	333:343	Mutation blocking phosphorylation signal	0.6944
p.S346Y	DO20786	KIRP	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation blocking phosphorylation signal	0.6944
p.A154E	DO228971	LICA	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1667
p.T129N	DO229019	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation altering degron motif	0.7055
p.A353D	DO229026	LICA	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.0556
p.T132K	DO229034	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation altering degron motif	0.6195
p.A125D	DO229009	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.2778
p.A125D	SIDM00120	Prostate Carcinoma	GDSC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.2778
p.A125D	ACH-000979	Prostate Cancer	CCLE	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.2778
p.A125D	DU-145	prostate	COSMIC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.2778
p.R323G	DO232761	PBCA	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.0556
p.P160L	DO232761	PBCA	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.7582
p.S152I	DO232224	PBCA	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1111
p.K159E	DO229456	SKCA	ICGC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.P328T	DO48001	STAD	ICGC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.1944
p.E332G	SIDM00565	Oral Cavity Carcinoma	GDSC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.3056
p.E332G	ACH-001626	Head and Neck Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.3056
p.E332G	OSC-20	upper aerodigestive tract	COSMIC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.3056
p.R323W	SIDM00878	Breast Carcinoma	GDSC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.0556
p.R323W	ACH-000930	Breast Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.0556
p.R323W	HCC1569	breast	COSMIC	NGGGQGYSSGP	CBL_PTK	333:343	Mutation rewiring degron network	0.0556
p.V127I	SIDM00519	Mesothelioma	GDSC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation altering degron motif	0.5965
p.V127I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation altering degron motif	0.5965
p.R157H	Farage	haematopoietic and lymphoid tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.R157H	OE33	oesophagus	COSMIC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.E174G	OSC-20	upper aerodigestive tract	COSMIC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.0556
p.R165W	HCC1569	breast	COSMIC	PYTSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.A135T	NCI-H2342	lung	COSMIC	VSTPETT	DEG_SCF_FBW7_1	127:133	Mutation rewiring degron network	0.2778

Kaplan plot for CD34 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD34

UniProt ID: P28906

Entrez ID: 947

Protein name: Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD34 in