DegronMD

Uniprot ID: P28906

Source protein: Hematopoietic progenitor cell antigen CD34

Source gene: CD34

Class: CBL_PTK

Location: 333:343

E3 ligase: CBL

DEGRON score: 0.8463

ASA_SCORE: 65.7

COIL: 0.7222

CONS_SCORE: 0.4671

DSS_SCORE: 0.6812

HELIX: 0.0347

FCONS_SCORE: 0.9207

RIG_SCORE: 0.5417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E326K	TCGA-04-1331	OV	TCGA	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	TCGA-AP-A0LM	UCEC	TCGA	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	TCGA-C8-A26Y	BRCA	TCGA	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	TCGA-PE-A5DE	BRCA	TCGA	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	DO1273	BRCA	ICGC	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	DO219643	BRCA	ICGC	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	DO28119	OV	ICGC	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	DO43306	UCEC	ICGC	NGGGQGYSSGP	CBL_PTK	0.1389
p.E326K	ACH-001518	Endometrial/Uterine Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	0.1389
p.G335V	TCGA-55-8089	LUAD	TCGA	NGGGQGYSSGP	CBL_PTK	0.6421
p.G335V	DO23690	LUAD	ICGC	NGGGQGYSSGP	CBL_PTK	0.6421
p.G342V	TCGA-56-6546	LUSC	TCGA	NGGGQGYSSGP	CBL_PTK	0.6421
p.G342V	DO26542	LUSC	ICGC	NGGGQGYSSGP	CBL_PTK	0.6421
p.P347L	TCGA-CF-A27C	BLCA	TCGA	NGGGQGYSSGP	CBL_PTK	0.2222
p.P347L	DO828	BLCA	ICGC	NGGGQGYSSGP	CBL_PTK	0.2222
p.P347H	TCGA-D9-A1X3	SKCM	TCGA	NGGGQGYSSGP	CBL_PTK	0.2222
p.P347T	TCGA-EE-A29E	SKCM	TCGA	NGGGQGYSSGP	CBL_PTK	0.2222
p.T331A	TCGA-F7-A624	HNSC	TCGA	NGGGQGYSSGP	CBL_PTK	0.7222
p.S346Y	TCGA-HE-7129	KIRP	TCGA	NGGGQGYSSGP	CBL_PTK	0.6944
p.S346Y	DO20786	KIRP	ICGC	NGGGQGYSSGP	CBL_PTK	0.6944
p.A353D	DO229026	LICA	ICGC	NGGGQGYSSGP	CBL_PTK	0.0556
p.R323G	DO232761	PBCA	ICGC	NGGGQGYSSGP	CBL_PTK	0.0556
p.P328T	DO48001	STAD	ICGC	NGGGQGYSSGP	CBL_PTK	0.1944
p.E332G	SIDM00565	Oral Cavity Carcinoma	GDSC	NGGGQGYSSGP	CBL_PTK	0.3056
p.E332G	ACH-001626	Head and Neck Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	0.3056
p.E332G	OSC-20	upper_aerodigestive_tract	COSMIC	NGGGQGYSSGP	CBL_PTK	0.3056
p.R323W	SIDM00878	Breast Carcinoma	GDSC	NGGGQGYSSGP	CBL_PTK	0.0556
p.R323W	ACH-000930	Breast Cancer	CCLE	NGGGQGYSSGP	CBL_PTK	0.0556
p.R323W	HCC1569	breast	COSMIC	NGGGQGYSSGP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28906	Hematopoietic progenitor cell antigen CD34	CBL_PTK	333:343	NGGGQGYSSGP	CBL	0.8463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NGGGQGYSSGP

Degron related mutations and impact score

Drug responses associated with CD34 mutations

All proteins holding degron of NGGGQGYSSGP