DegronMD

Uniprot ID: P28906

Source protein: Hematopoietic progenitor cell antigen CD34

Source gene: CD34

Class: DEG_SPOP_SBC_1

Location: 160:164

E3 ligase: SPOP

DEGRON score: 0.596

ASA_SCORE: 83.6

COIL: 0.8732

CONS_SCORE: 0.4098

DSS_SCORE: 0.4511

HELIX: 0.0268

FCONS_SCORE: 0.7993

RIG_SCORE: 0.6861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T155I	TCGA-17-Z017	LUAD	TCGA	PYTSS	DEG_SPOP_SBC_1	0.1944
p.S165Y	TCGA-BK-A6W3	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.3056
p.S165Y	DO222762	COCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.S165Y	DO50076	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.S165Y	SIDM01588	Endometrial Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.S165Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PYTSS	DEG_SPOP_SBC_1	0.3056
p.P157L	TCGA-CV-6956	HNSC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.25
p.P157L	DO15815	HNSC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.25
p.A154E	DO228971	LICA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1667
p.P160L	DO232761	PBCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.7582
p.S152I	DO232224	PBCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1111
p.K159E	DO229456	SKCA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.R157H	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.25
p.R157H	OE33	oesophagus	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.25
p.E174G	OSC-20	upper_aerodigestive_tract	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.0556
p.R165W	HCC1569	breast	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_SPOP_SBC_1	276:280	PYTSS	SPOP	0.8022	More...
O75925	E3 SUMO-protein ligase PIAS1	DEG_SPOP_SBC_1	582:586	PYTSS	SPOP	0.8855	More...
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SPOP_SBC_1	160:164	PYTSS	SPOP	0.596	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	1531:1535	PYTSS	SPOP	0.9971	More...
A6NJB7	Proline-rich protein 19	DEG_SPOP_SBC_1	242:246	PYTSS	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons