DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_SPOP_SBC_1

Location: 1531:1535

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 69.02

COIL: 0.8778

CONS_SCORE: 0.2827

DSS_SCORE: 0.5612

HELIX: 0.0764

FCONS_SCORE: 0.9746

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1528A	TCGA-5P-A9JW	KIRP	TCGA	PYTSS	DEG_SPOP_SBC_1	0.6944
p.T1528A	DO223943	KIRP	ICGC	PYTSS	DEG_SPOP_SBC_1	0.6944
p.R1541H	TCGA-A5-A0G2	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.1667
p.R1541H	DO41235	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1667
p.S1535Y	TCGA-AP-A1DV	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.712
p.S1535Y	DO43186	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.712
p.A1536V	TCGA-BG-A222	UCEC	TCGA	PYTSS	DEG_SPOP_SBC_1	0.3056
p.A1536V	DO42977	UCEC	ICGC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.R1541C	DO233245	GACA	ICGC	PYTSS	DEG_SPOP_SBC_1	0.1667
p.R1537Q	SIDM01282	Colorectal Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	0.2778
p.R1537Q	SIDM00841	Colorectal Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	0.2778
p.R1537Q	SW620	large_intestine	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.2778
p.E1530A	NCI-H1304	lung	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.E1530K	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.3056
p.E1542A	NCI-H1304	lung	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.25
p.E1542K	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	PYTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00482	Nuclear receptor subfamily 5 group A member 2	DEG_SPOP_SBC_1	276:280	PYTSS	SPOP	0.8022	More...
O75925	E3 SUMO-protein ligase PIAS1	DEG_SPOP_SBC_1	582:586	PYTSS	SPOP	0.8855	More...
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SPOP_SBC_1	160:164	PYTSS	SPOP	0.596	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	1531:1535	PYTSS	SPOP	0.9971	More...
A6NJB7	Proline-rich protein 19	DEG_SPOP_SBC_1	242:246	PYTSS	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons