DegronMD - A6NJB7(PRR19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R112S	TCGA-49-AARE	LUAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.0556
p.R112S	DO218922	LUAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.0556
p.D122N	TCGA-A5-A0G2	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation altering degron motif	0.5821
p.D122N	DO41235	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation altering degron motif	0.5821
p.P128S	TCGA-AB-2807	LAML	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2778
p.P128S	DO21589	LAML	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2778
p.G130C	TCGA-B5-A3FC	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.G130C	DO41871	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.F237L	TCGA-CI-6620	READ	TCGA	PYTSS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1944
p.F237L	DO36825	READ	ICGC	PYTSS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1944
p.P118A	TCGA-CV-A6JD	HNSC	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.P118A	DO49035	HNSC	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.P118T	TCGA-F1-6874	STAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.P118T	DO38201	STAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.A117T	TCGA-HF-A5NB	STAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.1944
p.A117T	DO50127	STAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.1944
p.P118S	TCGA-P5-A5ET	LGG	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.P118S	DO50158	LGG	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2222
p.R119W	TCGA-VD-A8KJ	UVM	TCGA	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.25
p.R119W	SIDM02026	Colorectal Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.25
p.A117S	DO229035	LICA	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.1944
p.A117S	DO229041	LICA	ICGC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.1944
p.P135L	SIDM00061	Ovarian Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.0833
p.A250G	SIDM01318	Hepatocellular Carcinoma	GDSC	PYTSS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.2222
p.A250G	ACH-001318	Liver Cancer	CCLE	PYTSS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.2222
p.S120Y	ACH-000681	Lung Cancer	CCLE	DKENQ	DEG_APCC_KENBOX_2	122:126	Mutation rewiring degron network	0.2778

Kaplan plot for PRR19 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR19

UniProt ID: A6NJB7

Entrez ID: 284338

Protein name: Proline-rich protein 19

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR19 in