DegronMD

Uniprot ID: A6NJB7

Source protein: Proline-rich protein 19

Source gene: PRR19

Class: DEG_APCC_KENBOX_2

Location: 122:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.964

ASA_SCORE: 112.86

COIL: 0.8568

CONS_SCORE: 0.8236

DSS_SCORE: 0.9061

HELIX: 0.1122

FCONS_SCORE: 1.2135

RIG_SCORE: 0.5556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R112S	TCGA-49-AARE	LUAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.0556
p.R112S	DO218922	LUAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.0556
p.D122N	TCGA-A5-A0G2	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.5821
p.D122N	DO41235	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.5821
p.P128S	TCGA-AB-2807	LAML	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.2778
p.P128S	DO21589	LAML	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.2778
p.G130C	TCGA-B5-A3FC	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.G130C	DO41871	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.P118A	TCGA-CV-A6JD	HNSC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.P118A	DO49035	HNSC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.P118T	TCGA-F1-6874	STAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.P118T	DO38201	STAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.A117T	TCGA-HF-A5NB	STAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1944
p.A117T	DO50127	STAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1944
p.P118S	TCGA-P5-A5ET	LGG	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.P118S	DO50158	LGG	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.R119W	TCGA-VD-A8KJ	UVM	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.25
p.R119W	SIDM02026	Colorectal Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.25
p.A117S	DO229035	LICA	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1944
p.A117S	DO229041	LICA	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1944
p.P135L	SIDM00061	Ovarian Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.0833
p.S120Y	ACH-000681	Lung Cancer	CCLE	DKENQ	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P67809	Y-box-binding protein 1	DEG_APCC_KENBOX_2	263:267	DKENQ	APC,CDC20,FZR1	0.5688	More...
A6NJB7	Proline-rich protein 19	DEG_APCC_KENBOX_2	122:126	DKENQ	APC,CDC20,FZR1	0.964	More...
Q99618	Cell division cycle-associated protein 3	DEG_APCC_KENBOX_2	257:261	DKENQ	APC,CDC20,FZR1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons