DegronMD

Uniprot ID: Q99618

Source protein: Cell division cycle-associated protein 3

Source gene: CDCA3

Class: DEG_APCC_KENBOX_2

Location: 257:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9977

ASA_SCORE: 96.08

COIL: 0.6094

CONS_SCORE: 0.7212

DSS_SCORE: 0.6878

HELIX: 0.3474

FCONS_SCORE: 1.3167

RIG_SCORE: 0.6933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W250R	TCGA-AG-A036	READ	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.H262Q	TCGA-AX-A1CE	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.3056
p.W250C	TCGA-EE-A29L	SKCM	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.G253S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P67809	Y-box-binding protein 1	DEG_APCC_KENBOX_2	263:267	DKENQ	APC,CDC20,FZR1	0.5688	More...
A6NJB7	Proline-rich protein 19	DEG_APCC_KENBOX_2	122:126	DKENQ	APC,CDC20,FZR1	0.964	More...
Q99618	Cell division cycle-associated protein 3	DEG_APCC_KENBOX_2	257:261	DKENQ	APC,CDC20,FZR1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons