DegronMD

Uniprot ID: P67809

Source protein: Y-box-binding protein 1

Source gene: YBX1

Class: DEG_APCC_KENBOX_2

Location: 263:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5688

ASA_SCORE: 109.8

COIL: 0.7672

CONS_SCORE: 0.301

DSS_SCORE: 0.8996

HELIX: 0.2196

FCONS_SCORE: 0.8862

RIG_SCORE: 0.5647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N266S	TCGA-A2-A1G4	BRCA	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.7069
p.N266S	DO1259	BRCA	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.7069
p.R253T	TCGA-A5-A0VP	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.0556
p.R253T	DO42600	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.0556
p.Q274P	TCGA-BR-8081	STAD	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.Q274P	DO38795	STAD	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.R256T	TCGA-D1-A1NZ	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.R256T	DO41536	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1389
p.E257K	TCGA-EO-A22U	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	0.1667
p.E257K	DO43755	UCEC	ICGC	DKENQ	DEG_APCC_KENBOX_2	0.1667
p.Q267H	SIDM00789	Colorectal Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.647
p.Q267H	HCT-15	large_intestine	COSMIC	DKENQ	DEG_APCC_KENBOX_2	0.647
p.G268R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.3056
p.G268R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DKENQ	DEG_APCC_KENBOX_2	0.3056
p.G259D	SIDM00217	Colorectal Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.G259D	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENQ	DEG_APCC_KENBOX_2	0.2222
p.G259D	SNU-1040	large_intestine	COSMIC	DKENQ	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P67809	Y-box-binding protein 1	DEG_APCC_KENBOX_2	263:267	DKENQ	APC,CDC20,FZR1	0.5688	More...
A6NJB7	Proline-rich protein 19	DEG_APCC_KENBOX_2	122:126	DKENQ	APC,CDC20,FZR1	0.964	More...
Q99618	Cell division cycle-associated protein 3	DEG_APCC_KENBOX_2	257:261	DKENQ	APC,CDC20,FZR1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons