DegronMD - Q99618(CDCA3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I73V	TCGA-27-1838	GBM	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.5965
p.I73V	DO12154	GBM	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.5965
p.G182C	TCGA-2W-A8YY	CESC	TCGA	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.3056
p.T76K	TCGA-35-4122	LUAD	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.8417
p.T76K	DO23782	LUAD	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.8417
p.D65Y	TCGA-5G-A9ZZ	THYM	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1111
p.S172L	TCGA-A8-A094	BRCA	TCGA	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.S172L	TCGA-A8-A094	BRCA	TCGA	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.25
p.S172L	DO2593	BRCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.S172L	DO2593	BRCA	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.25
p.P85H	TCGA-AA-3811	COAD	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1944
p.P85H	DO7962	COAD	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1944
p.W250R	TCGA-AG-A036	READ	TCGA	DKENQ	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.R185H	TCGA-AP-A059	UCEC	TCGA	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2222
p.H262Q	TCGA-AX-A1CE	UCEC	TCGA	DKENQ	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.3056
p.I203T	TCGA-AX-A1CE	UCEC	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.5966
p.P66S	TCGA-AX-A1CE	UCEC	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1389
p.P66S	DO42280	UCEC	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1389
p.P210L	TCGA-B5-A1MX	UCEC	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1944
p.K194N	TCGA-BF-A1Q0	SKCM	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation substituting flanking lysine	0.3611
p.S165T	TCGA-CD-8528	STAD	TCGA	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7116
p.S165T	DO47729	STAD	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7116
p.M78I	TCGA-CU-A3KJ	BLCA	TCGA	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.6507
p.M78I	DO663	BLCA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.6507
p.Q148E	TCGA-DI-A0WH	UCEC	TCGA	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.0556
p.Q148E	DO43843	UCEC	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.0556
p.S183Y	TCGA-DU-6392	LGG	TCGA	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2778
p.W250C	TCGA-EE-A29L	SKCM	TCGA	DKENQ	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.P162L	TCGA-EE-A3AE	SKCM	TCGA	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7582
p.P162L	DO37802	SKCM	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7582
p.T159K	TCGA-XF-A9SK	BLCA	TCGA	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7306
p.T159K	DO223596	BLCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7306
p.R185C	TCGA-XK-AAIW	PRAD	TCGA	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2222
p.R185C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2222
p.R185C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2222
p.P201H	DO708	BLCA	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7694
p.A182S	DO223732	CESC	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.3056
p.R195W	DO8490	COAD	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.A155S	DO224754	COCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.25
p.V202I	DO222492	COCA	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7076
p.R173M	DO222864	COCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1111
p.R173M	DO222864	COCA	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2778
p.R67C	DO223029	ESCA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.S158Y	DO22237	LGG	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.712
p.Q180K	DO228952	LICA	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation altering degron motif	0.6944
p.S167R	DO229029	LICA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation blocking phosphorylation signal	0.7222
p.S167R	DO229029	LICA	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation blocking phosphorylation signal	0.5556
p.Q157K	DO229031	LICA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.3056
p.P88Q	DO229037	LICA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1111
p.R191Q	DO230961	LUSC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1667
p.R191Q	DO230961	LUSC	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.0556
p.R191Q	DO224594	LUSC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1667
p.R191Q	DO224594	LUSC	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.0556
p.R160C	DO232878	PEME	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8301
p.R160C	DO51407	PRAD	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8301
p.R160C	ACH-001127	Leukemia	CCLE	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8301
p.R160C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8301
p.P193Q	DO37450	SKCM	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2222
p.K169N	DO47374	SKCM	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2222
p.K169N	DO47374	SKCM	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.1667
p.K194E	DO42023	UCEC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation substituting flanking lysine	0.3611
p.I178T	DO42280	UCEC	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation altering degron motif	0.7078
p.P185L	DO41999	UCEC	ICGC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.2222
p.R160H	DO41361	UCEC	ICGC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8244
p.P158S	SIDM01307	Colorectal Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.P158S	SIDM01194	Hepatocellular Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.P158S	SNU-449	liver	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.A74T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.6028
p.A74T	ACH-000983	Leukemia	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.6028
p.A74T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.6028
p.A74V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.5825
p.R187S	SIDM00541	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0556
p.R187S	SIDM00541	Colorectal Carcinoma	GDSC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.1667
p.R187S	HT55	large intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.0556
p.R187S	HT55	large intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation rewiring degron network	0.1667
p.R67H	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	SIDM00687	Gastric Carcinoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	SIDM00026	Other Solid Cancers	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	ACH-000697	Lymphoma	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	ACH-000793	Gastric Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	ACH-001277	Sarcoma	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	ACH-001670	Brain Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.R67H	TASK1	bone	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1667
p.T202I	SIDM00282	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7078
p.T202I	CW-2	large intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7078
p.E153D	SIDM00596	Endometrial Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1944
p.E153D	HEC-1	endometrium	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1944
p.K189N	SIDM00498	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation blocking ubiquitination signal	0.5556
p.K189N	SIDM00498	Colorectal Carcinoma	GDSC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation blocking ubiquitination signal	0.5556
p.K189N	SNU-C5	large intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation blocking ubiquitination signal	0.5556
p.K189N	SNU-C5	large intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation blocking ubiquitination signal	0.5556
p.P77H	SIDM00498	Colorectal Carcinoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.7694
p.P77H	SNU-C5	large intestine	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation altering degron motif	0.7694
p.G253S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DKENQ	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.2222
p.P88S	ACH-000709	Kidney Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1111
p.P88S	ACH-001517	Endometrial/Uterine Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1111
p.P88S	HEC-1	endometrium	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	73:80	Mutation rewiring degron network	0.1111
p.R162S	ACH-000926	Colon/Colorectal Cancer	CCLE	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7427
p.R162S	HT55	large intestine	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7427
p.K164N	ACH-000970	Colon/Colorectal Cancer	CCLE	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6918
p.K164N	SNU-C5	large intestine	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6918
p.T177I	ACH-000998	Colon/Colorectal Cancer	CCLE	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation altering degron motif	0.8189
p.T177I	CW-2	large intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	175:181	Mutation altering degron motif	0.8189
p.G213R	ACH-001842	Bile Duct Cancer	CCLE	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.1111
p.A209T	NCI-H1944	lung	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation blocking phosphorylation signal	0.6667
p.C204R	LN-405	central nervous system	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.8301
p.R195Q	AN3-CA	endometrium	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.R195Q	NCI-H1304	lung	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation rewiring degron network	0.2778
p.D205G	LS-180	large intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	197:205	Mutation altering degron motif	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCA3

UniProt ID: Q99618

Entrez ID: 83461

Protein name: Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCA3 in