DegronMD

Uniprot ID: Q99618

Source protein: Cell division cycle-associated protein 3

Source gene: CDCA3

Class: DEG_APCC_DBOX_1

Location: 197:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9703

ASA_SCORE: 60.5889

COIL: 0.6469

CONS_SCORE: 0.6751

DSS_SCORE: 0.6278

HELIX: 0.0582

FCONS_SCORE: 1.1253

RIG_SCORE: 0.7024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I203T	TCGA-AX-A1CE	UCEC	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	0.5966
p.P210L	TCGA-B5-A1MX	UCEC	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	0.1944
p.K194N	TCGA-BF-A1Q0	SKCM	TCGA	GRSPLTILQ	DEG_APCC_DBOX_1	0.3611
p.P201H	DO708	BLCA	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.7694
p.R195W	DO8490	COAD	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.2778
p.V202I	DO222492	COCA	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.7076
p.R191Q	DO230961	LUSC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.1667
p.R191Q	DO224594	LUSC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.1667
p.P193Q	DO37450	SKCM	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.2222
p.K194E	DO42023	UCEC	ICGC	GRSPLTILQ	DEG_APCC_DBOX_1	0.3611
p.R187S	SIDM00541	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	0.0556
p.R187S	HT55	large_intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.0556
p.T202I	SIDM00282	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	0.7078
p.T202I	CW-2	large_intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.7078
p.K189N	SIDM00498	Colorectal Carcinoma	GDSC	GRSPLTILQ	DEG_APCC_DBOX_1	0.5556
p.K189N	SNU-C5	large_intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.5556
p.G213R	ACH-001842	Bile Duct Cancer	CCLE	GRSPLTILQ	DEG_APCC_DBOX_1	0.1111
p.A209T	NCI-H1944	lung	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.6667
p.C204R	LN-405	central_nervous_system	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.8301
p.R195Q	AN3-CA	endometrium	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.2778
p.R195Q	NCI-H1304	lung	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.2778
p.D205G	LS-180	large_intestine	COSMIC	GRSPLTILQ	DEG_APCC_DBOX_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99618	Cell division cycle-associated protein 3	DEG_APCC_DBOX_1	197:205	GRSPLTILQ	APC,CDC20,FZR1	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons