DegronMD

Uniprot ID: Q99618

Source protein: Cell division cycle-associated protein 3

Source gene: CDCA3

Class: DEG_SCF_FBW7_1

Location: 158:165

E3 ligase: FBXW7

DEGRON score: 0.9904

ASA_SCORE: 82.325

COIL: 0.9284

CONS_SCORE: 0.5099

DSS_SCORE: 0.7763

HELIX: 0.0304

FCONS_SCORE: 0.9816

RIG_SCORE: 0.602

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S172L	TCGA-A8-A094	BRCA	TCGA	PTETPVAS	DEG_SCF_FBW7_1	0.1389
p.S172L	DO2593	BRCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.1389
p.S165T	TCGA-CD-8528	STAD	TCGA	PTETPVAS	DEG_SCF_FBW7_1	0.7116
p.S165T	DO47729	STAD	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.7116
p.Q148E	TCGA-DI-A0WH	UCEC	TCGA	PTETPVAS	DEG_SCF_FBW7_1	0.0556
p.Q148E	DO43843	UCEC	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.0556
p.P162L	TCGA-EE-A3AE	SKCM	TCGA	PTETPVAS	DEG_SCF_FBW7_1	0.7582
p.P162L	DO37802	SKCM	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.7582
p.T159K	TCGA-XF-A9SK	BLCA	TCGA	PTETPVAS	DEG_SCF_FBW7_1	0.7306
p.T159K	DO223596	BLCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.7306
p.A155S	DO224754	COCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.25
p.R173M	DO222864	COCA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.1111
p.S158Y	DO22237	LGG	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.712
p.S167R	DO229029	LICA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.7222
p.Q157K	DO229031	LICA	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.3056
p.R160C	DO232878	PEME	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.8301
p.R160C	DO51407	PRAD	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.8301
p.R160C	ACH-001127	Leukemia	CCLE	PTETPVAS	DEG_SCF_FBW7_1	0.8301
p.R160C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	0.8301
p.K169N	DO47374	SKCM	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.2222
p.R160H	DO41361	UCEC	ICGC	PTETPVAS	DEG_SCF_FBW7_1	0.8244
p.P158S	SIDM01307	Colorectal Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	0.6752
p.P158S	SIDM01194	Hepatocellular Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	0.6752
p.P158S	SNU-449	liver	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	0.6752
p.E153D	SIDM00596	Endometrial Carcinoma	GDSC	PTETPVAS	DEG_SCF_FBW7_1	0.1944
p.E153D	HEC-1	endometrium	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	0.1944
p.R162S	ACH-000926	Colon/Colorectal Cancer	CCLE	PTETPVAS	DEG_SCF_FBW7_1	0.7427
p.R162S	HT55	large_intestine	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	0.7427
p.K164N	ACH-000970	Colon/Colorectal Cancer	CCLE	PTETPVAS	DEG_SCF_FBW7_1	0.6918
p.K164N	SNU-C5	large_intestine	COSMIC	PTETPVAS	DEG_SCF_FBW7_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTETPVAS

Degron related mutations and impact score

Drug responses associated with CDCA3 mutations

All proteins holding degron of PTETPVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99618	Cell division cycle-associated protein 3	DEG_SCF_FBW7_1	158:165	PTETPVAS	FBXW7	0.9904	More...