DegronMD

Uniprot ID: Q99618

Source protein: Cell division cycle-associated protein 3

Source gene: CDCA3

Class: DEG_SCF_FBW7_1

Location: 73:80

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 65.65

COIL: 0.723

CONS_SCORE: 0.8167

DSS_SCORE: 0.743

HELIX: 0.0294

FCONS_SCORE: 1.2359

RIG_SCORE: 0.6299

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I73V	TCGA-27-1838	GBM	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.5965
p.I73V	DO12154	GBM	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.5965
p.T76K	TCGA-35-4122	LUAD	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.8417
p.T76K	DO23782	LUAD	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.8417
p.D65Y	TCGA-5G-A9ZZ	THYM	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.1111
p.P85H	TCGA-AA-3811	COAD	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.1944
p.P85H	DO7962	COAD	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.1944
p.P66S	TCGA-AX-A1CE	UCEC	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.1389
p.P66S	DO42280	UCEC	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.1389
p.M78I	TCGA-CU-A3KJ	BLCA	TCGA	IARTPMKT	DEG_SCF_FBW7_1	0.6507
p.M78I	DO663	BLCA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.6507
p.R67C	DO223029	ESCA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.P88Q	DO229037	LICA	ICGC	IARTPMKT	DEG_SCF_FBW7_1	0.1111
p.A74T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.6028
p.A74T	ACH-000983	Leukemia	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.6028
p.A74T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	0.6028
p.A74V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.5825
p.R67H	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	SIDM00687	Gastric Carcinoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	SIDM00026	Other Solid Cancers	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	ACH-000697	Lymphoma	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	ACH-000793	Gastric Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	ACH-001277	Sarcoma	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	ACH-001670	Brain Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.R67H	TASK1	bone	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	0.1667
p.P77H	SIDM00498	Colorectal Carcinoma	GDSC	IARTPMKT	DEG_SCF_FBW7_1	0.7694
p.P77H	SNU-C5	large_intestine	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	0.7694
p.P88S	ACH-000709	Kidney Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1111
p.P88S	ACH-001517	Endometrial/Uterine Cancer	CCLE	IARTPMKT	DEG_SCF_FBW7_1	0.1111
p.P88S	HEC-1	endometrium	COSMIC	IARTPMKT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IARTPMKT

Degron related mutations and impact score

Drug responses associated with CDCA3 mutations

All proteins holding degron of IARTPMKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99618	Cell division cycle-associated protein 3	DEG_SCF_FBW7_1	73:80	IARTPMKT	FBXW7	0.9968	More...