DegronMD

Uniprot ID: Q99618

Source protein: Cell division cycle-associated protein 3

Source gene: CDCA3

Class: DEG_SCF_FBW7_1

Location: 175:181

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 86.5286

COIL: 0.9283

CONS_SCORE: 0.6176

DSS_SCORE: 0.7897

HELIX: 0.0316

FCONS_SCORE: 1.127

RIG_SCORE: 0.541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G182C	TCGA-2W-A8YY	CESC	TCGA	PETPRSS	DEG_SCF_FBW7_1	0.3056
p.S172L	TCGA-A8-A094	BRCA	TCGA	PETPRSS	DEG_SCF_FBW7_1	0.25
p.S172L	DO2593	BRCA	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.25
p.R185H	TCGA-AP-A059	UCEC	TCGA	PETPRSS	DEG_SCF_FBW7_1	0.2222
p.S183Y	TCGA-DU-6392	LGG	TCGA	PETPRSS	DEG_SCF_FBW7_1	0.2778
p.R185C	TCGA-XK-AAIW	PRAD	TCGA	PETPRSS	DEG_SCF_FBW7_1	0.2222
p.R185C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PETPRSS	DEG_SCF_FBW7_1	0.2222
p.R185C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PETPRSS	DEG_SCF_FBW7_1	0.2222
p.A182S	DO223732	CESC	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.3056
p.R173M	DO222864	COCA	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.2778
p.Q180K	DO228952	LICA	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.6944
p.S167R	DO229029	LICA	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.5556
p.R191Q	DO230961	LUSC	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.0556
p.R191Q	DO224594	LUSC	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.0556
p.K169N	DO47374	SKCM	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.1667
p.I178T	DO42280	UCEC	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.7078
p.P185L	DO41999	UCEC	ICGC	PETPRSS	DEG_SCF_FBW7_1	0.2222
p.R187S	SIDM00541	Colorectal Carcinoma	GDSC	PETPRSS	DEG_SCF_FBW7_1	0.1667
p.R187S	HT55	large_intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	0.1667
p.K189N	SIDM00498	Colorectal Carcinoma	GDSC	PETPRSS	DEG_SCF_FBW7_1	0.5556
p.K189N	SNU-C5	large_intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	0.5556
p.T177I	ACH-000998	Colon/Colorectal Cancer	CCLE	PETPRSS	DEG_SCF_FBW7_1	0.8189
p.T177I	CW-2	large_intestine	COSMIC	PETPRSS	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99618	Cell division cycle-associated protein 3	DEG_SCF_FBW7_1	175:181	PETPRSS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons