DegronMD

Uniprot ID: P28906

Source protein: Hematopoietic progenitor cell antigen CD34

Source gene: CD34

Class: DEG_SCF_FBW7_1

Location: 127:133

E3 ligase: FBXW7

DEGRON score: 0.9512

ASA_SCORE: 83.7429

COIL: 0.8774

CONS_SCORE: 0.5274

DSS_SCORE: 0.5154

HELIX: 0.0263

FCONS_SCORE: 1.0616

RIG_SCORE: 0.7299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P124T	TCGA-55-7907	LUAD	TCGA	VSTPETT	DEG_SCF_FBW7_1	0.25
p.P124T	DO25396	LUAD	ICGC	VSTPETT	DEG_SCF_FBW7_1	0.25
p.I117T	TCGA-AJ-A5DW	UCEC	TCGA	VSTPETT	DEG_SCF_FBW7_1	0.0556
p.I117T	DO50075	UCEC	ICGC	VSTPETT	DEG_SCF_FBW7_1	0.0556
p.T129N	DO229019	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	0.7055
p.T132K	DO229034	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	0.6195
p.A125D	DO229009	LICA	ICGC	VSTPETT	DEG_SCF_FBW7_1	0.2778
p.A125D	SIDM00120	Prostate Carcinoma	GDSC	VSTPETT	DEG_SCF_FBW7_1	0.2778
p.A125D	ACH-000979	Prostate Cancer	CCLE	VSTPETT	DEG_SCF_FBW7_1	0.2778
p.A125D	DU-145	prostate	COSMIC	VSTPETT	DEG_SCF_FBW7_1	0.2778
p.V127I	SIDM00519	Mesothelioma	GDSC	VSTPETT	DEG_SCF_FBW7_1	0.5965
p.V127I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPETT	DEG_SCF_FBW7_1	0.5965
p.A135T	NCI-H2342	lung	COSMIC	VSTPETT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28906	Hematopoietic progenitor cell antigen CD34	DEG_SCF_FBW7_1	127:133	VSTPETT	FBXW7	0.9512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons